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Dusp3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) [ Mus musculus (house mouse) ]

Gene ID: 72349, updated on 2-Oct-2018

Summary

Official Symbol
Dusp3provided by MGI
Official Full Name
dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)provided by MGI
Primary source
MGI:MGI:1919599
See related
Ensembl:ENSMUSG00000003518 Vega:OTTMUSG00000002139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VHR; T-DSP11; 2210015O03Rik; 5031436O03Rik
Expression
Ubiquitous expression in lung adult (RPKM 26.0), cortex adult (RPKM 23.2) and 28 other tissues See more
Orthologs

Genomic context

See Dusp3 in Genome Data Viewer
Location:
11; 11 D
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (101971141..101987005, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101835473..101846084, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930417O22 gene Neighboring gene sclerostin Neighboring gene CFAP97 domain containing 1 Neighboring gene membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
MAP kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
inactivation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of focal adhesion disassembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
immunological synapse ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 3
Names
vaccinia H1-related phosphatase
NP_082483.1
XP_006534368.1
XP_006534369.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028207.3NP_082483.1  dual specificity protein phosphatase 3

    See identical proteins and their annotated locations for NP_082483.1

    Status: VALIDATED

    Source sequence(s)
    AK008734, AL591145
    Consensus CDS
    CCDS25482.1
    UniProtKB/Swiss-Prot
    Q9D7X3
    Related
    ENSMUSP00000003612.6, OTTMUSP00000002061, ENSMUST00000003612.12, OTTMUST00000004348
    Conserved Domains (1) summary
    cd00127
    Location:29174
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    101971141..101987005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534306.1XP_006534369.1  dual specificity protein phosphatase 3 isoform X2

    Conserved Domains (1) summary
    cd00127
    Location:29174
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. XM_006534305.2XP_006534368.1  dual specificity protein phosphatase 3 isoform X1

    Conserved Domains (1) summary
    cd00127
    Location:54199
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
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