Format

Send to:

Choose Destination

Palld palladin, cytoskeletal associated protein [ Mus musculus (house mouse) ]

Gene ID: 72333, updated on 5-Aug-2018

Summary

Official Symbol
Palldprovided by MGI
Official Full Name
palladin, cytoskeletal associated proteinprovided by MGI
Primary source
MGI:MGI:1919583
See related
Ensembl:ENSMUSG00000058056 Vega:OTTMUSG00000031055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030492A02; 2410003B16Rik
Expression
Broad expression in bladder adult (RPKM 40.1), ovary adult (RPKM 20.2) and 21 other tissues See more
Orthologs

Genomic context

See Palld in Genome Data Viewer
Location:
8; 8 B3.1
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (61511429..61902700, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (63993818..64381487, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 1 Neighboring gene RIKEN cDNA 5730405A17 gene Neighboring gene carbonyl reductase 4 Neighboring gene predicted gene, 35254 Neighboring gene lysyl-tRNA synthetase pseudogene Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150248

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
axon guidance receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IEA
Inferred from Electronic Annotation
more info
 
epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratinocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
ruffle organization ISO
Inferred from Sequence Orthology
more info
 
synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
actin filament ISO
Inferred from Sequence Orthology
more info
 
actin filament ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
filopodium ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
podosome ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 
stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
palladin
Names
90kDa actin-associated protein palladin
palladin isoform

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081390.1NP_001074859.1  palladin isoform 4

    See identical proteins and their annotated locations for NP_001074859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) lacks two alternate internal segments and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121881, AC139846, AC147616
    Consensus CDS
    CCDS40350.1
    UniProtKB/Swiss-Prot
    Q9ET54
    Related
    ENSMUSP00000034057.7, ENSMUST00000034057.13
    Conserved Domains (3) summary
    cd00096
    Location:465542
    Ig; Immunoglobulin domain
    cd05893
    Location:10341108
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:278368
    I-set; Immunoglobulin I-set domain
  2. NM_001293772.1NP_001280701.1  palladin isoform 1

    See identical proteins and their annotated locations for NP_001280701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC121881, AK031696, AK052489, BB658601
    Consensus CDS
    CCDS80882.1
    UniProtKB/Swiss-Prot
    Q9ET54
    Related
    ENSMUSP00000112442.1, OTTMUSP00000040564, ENSMUST00000121785.8, OTTMUST00000076933
    Conserved Domains (3) summary
    cd00096
    Location:465542
    Ig; Immunoglobulin domain
    cd05893
    Location:12761350
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:278368
    I-set; Immunoglobulin I-set domain
  3. NM_001293773.1NP_001280702.1  palladin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC121881, AK076423, AK087270, JX477684
    Consensus CDS
    CCDS80881.1
    UniProtKB/TrEMBL
    K0BWC3
    Related
    ENSMUSP00000113874.1, OTTMUSP00000040566, ENSMUST00000121493.8, OTTMUST00000076936
    Conserved Domains (3) summary
    cd00096
    Location:76153
    Ig; Immunoglobulin domain
    cd05893
    Location:870944
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:754844
    I-set; Immunoglobulin I-set domain
  4. NM_001293774.1NP_001280703.1  palladin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC121881, AK149663, BY766661
    Consensus CDS
    CCDS80880.1
    UniProtKB/Swiss-Prot
    Q9ET54
    Related
    ENSMUSP00000112374.1, OTTMUSP00000040565, ENSMUST00000121200.8, OTTMUST00000076935
    Conserved Domains (3) summary
    cd00096
    Location:298367
    Ig; Immunoglobulin domain
    cd05893
    Location:531605
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:415505
    I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    61511429..61902700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509507.3XP_006509570.1  palladin isoform X4

    See identical proteins and their annotated locations for XP_006509570.1

    Conserved Domains (3) summary
    cd00096
    Location:315384
    Ig; Immunoglobulin domain
    cd05893
    Location:548622
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:432522
    I-set; Immunoglobulin I-set domain
  2. XM_006509508.3XP_006509571.1  palladin isoform X4

    See identical proteins and their annotated locations for XP_006509571.1

    Conserved Domains (3) summary
    cd00096
    Location:315384
    Ig; Immunoglobulin domain
    cd05893
    Location:548622
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:432522
    I-set; Immunoglobulin I-set domain
  3. XM_011242242.2XP_011240544.1  palladin isoform X1

    See identical proteins and their annotated locations for XP_011240544.1

    UniProtKB/Swiss-Prot
    Q9ET54
    Conserved Domains (3) summary
    cd00096
    Location:465542
    Ig; Immunoglobulin domain
    cd05893
    Location:12761350
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:278368
    I-set; Immunoglobulin I-set domain
  4. XM_006509503.2XP_006509566.1  palladin isoform X2

    UniProtKB/Swiss-Prot
    Q9ET54
    Conserved Domains (3) summary
    cd00096
    Location:465542
    Ig; Immunoglobulin domain
    cd05893
    Location:12591333
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:278368
    I-set; Immunoglobulin I-set domain
  5. XM_006509504.3XP_006509567.1  palladin isoform X3

    See identical proteins and their annotated locations for XP_006509567.1

    Conserved Domains (3) summary
    cd00096
    Location:76153
    Ig; Immunoglobulin domain
    cd05893
    Location:887961
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:771861
    I-set; Immunoglobulin I-set domain
  6. XM_006509505.3XP_006509568.1  palladin isoform X3

    See identical proteins and their annotated locations for XP_006509568.1

    Conserved Domains (3) summary
    cd00096
    Location:76153
    Ig; Immunoglobulin domain
    cd05893
    Location:887961
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:771861
    I-set; Immunoglobulin I-set domain
Support Center