Lsm11 U7 snRNP-specific Sm-like protein LSM11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lsm11provided by MGI
Official Full Name: U7 snRNP-specific Sm-like protein LSM11provided by MGI
Primary source: MGI:MGI:1919540
See related: Ensembl:ENSMUSG00000044847 AllianceGenome:MGI:1919540
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2210404M20Rik
Summary: Predicted to enable U7 snRNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Part of U7 snRNP and histone pre-mRNA 3'end processing complex. Is expressed in femur; nucleus pulposus; rib; thoracic segment skeleton; and turbinate bone primordium. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human LSM11 (LSM11, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 10.4), whole brain E14.5 (RPKM 7.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.1; 11 27.46 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (45819096..45835762, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (45928266..45944996, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Specifies the assembly of the U7 Sm core, also fulfills an important role in U7 snRNP-mediated histone mRNA processing.
Title: Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables U7 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U7 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U7 snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromatin organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of U7 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U7 snRNP	IDA Inferred from Direct Assay more info	PubMed
part_of U7 snRNP	ISO Inferred from Sequence Orthology more info
part_of U7 snRNP	ISS Inferred from Sequence or Structural Similarity more info
part_of histone pre-mRNA 3'end processing complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of telomerase holoenzyme complex	IEA Inferred from Electronic Annotation more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: U7 snRNA-associated Sm-like protein LSm11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.