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Tram1 translocating chain-associating membrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 72265, updated on 30-Apr-2024

Summary

Official Symbol
Tram1provided by MGI
Official Full Name
translocating chain-associating membrane protein 1provided by MGI
Primary source
MGI:MGI:1919515
See related
Ensembl:ENSMUSG00000025935 AllianceGenome:MGI:1919515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRAMP; 1810049E02Rik
Summary
This gene encodes a multi-pass transmembrane protein of the endoplasmic reticulum (ER). It is involved in the process of cotranslational translocation of secretory proteins into the ER. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in placenta adult (RPKM 47.6), testis adult (RPKM 32.3) and 28 other tissues See more
Orthologs
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Genomic context

See Tram1 in Genome Data Viewer
Location:
1 A3; 1 4.18 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13634917..13660134, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13564693..13589910, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39595 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene STARR-seq mESC enhancer starr_00273 Neighboring gene predicted gene, 39600 Neighboring gene STARR-seq mESC enhancer starr_00275 Neighboring gene STARR-seq mESC enhancer starr_00276 Neighboring gene STARR-seq mESC enhancer starr_00277 Neighboring gene STARR-seq mESC enhancer starr_00278 Neighboring gene STARR-seq mESC enhancer starr_00279 Neighboring gene lactamase, beta 2 Neighboring gene STARR-seq mESC enhancer starr_00283 Neighboring gene STARR-seq mESC enhancer starr_00284 Neighboring gene X-linked Kx blood group related 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC1174

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IEA
Inferred from Electronic Annotation
more info
 
involved_in cotranslational protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
translocating chain-associated membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028173.5NP_082449.1  translocating chain-associated membrane protein 1

    See identical proteins and their annotated locations for NP_082449.1

    Status: REVIEWED

    Source sequence(s)
    AC157769
    Consensus CDS
    CCDS14822.1
    UniProtKB/Swiss-Prot
    Q91V04
    UniProtKB/TrEMBL
    Q3UAT2, Q3UQ93, Q4FK14
    Related
    ENSMUSP00000027068.5, ENSMUST00000027068.11
    Conserved Domains (2) summary
    smart00724
    Location:117326
    TLC; TRAM, LAG1 and CLN8 homology domains
    pfam08390
    Location:47115
    TRAM1; TRAM1-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    13634917..13660134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)