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Kcnk10 potassium channel, subfamily K, member 10 [ Mus musculus (house mouse) ]

Gene ID: 72258, updated on 10-Oct-2024

Summary

Official Symbol
Kcnk10provided by MGI
Official Full Name
potassium channel, subfamily K, member 10provided by MGI
Primary source
MGI:MGI:1919508
See related
Ensembl:ENSMUSG00000033854 AllianceGenome:MGI:1919508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trek2; 1700024D23Rik; 3010005K24Rik
Summary
Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in cerebral cortex; early conceptus; and secondary oocyte. Orthologous to human KCNK10 (potassium two pore domain channel subfamily K member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 3.9), CNS E18 (RPKM 2.8) and 9 other tissues See more
Orthologs
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Genomic context

See Kcnk10 in Genome Data Viewer
Location:
12 E; 12 49.86 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (98395691..98544472, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (98429432..98578213, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene galactosylceramidase Neighboring gene STARR-positive B cell enhancer ABC_E8497 Neighboring gene STARR-positive B cell enhancer ABC_E8498 Neighboring gene STARR-positive B cell enhancer ABC_E5347 Neighboring gene STARR-positive B cell enhancer ABC_E11519 Neighboring gene G-protein coupled receptor 65 Neighboring gene STARR-positive B cell enhancer mm9_chr12:99698044-99698344 Neighboring gene predicted gene, 40893 Neighboring gene STARR-seq mESC enhancer starr_32997 Neighboring gene STARR-positive B cell enhancer mm9_chr12:99839121-99839422 Neighboring gene STARR-seq mESC enhancer starr_32998 Neighboring gene predicted gene, 25486 Neighboring gene spermatogenesis associated 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 10
Names
TREK-2 two-pore-domain K+ channel
outward rectifying potassium channel TREK2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316664.1NP_001303593.1  potassium channel subfamily K member 10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AC124516, AC134249, AK031904
    Consensus CDS
    CCDS88386.1
    UniProtKB/TrEMBL
    Q8BZB0
    Related
    ENSMUSP00000105740.3, ENSMUST00000110113.3
    Conserved Domains (1) summary
    pfam07885
    Location:135189
    Ion_trans_2; Ion channel
  2. NM_001316665.1NP_001303594.1  potassium channel subfamily K member 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC124516, AC134249, AK019376, AK031904
    UniProtKB/TrEMBL
    Q3LS20, Q8BZB0
    Conserved Domains (1) summary
    pfam07885
    Location:152206
    Ion_trans_2; Ion channel
  3. NM_001316666.1NP_001303595.1  potassium channel subfamily K member 10 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the UTRs and coding sequence compared to variant 3. The resulting isoform (4) has shorter and distinct N- and C-termini compared to isoform 3.
    Source sequence(s)
    AC134249, AK019376
    Consensus CDS
    CCDS88385.1
    Related
    ENSMUSP00000152656.2, ENSMUST00000221305.2
    Conserved Domains (1) summary
    pfam07885
    Location:148206
    Ion_trans_2; Ion channel
  4. NM_029911.5NP_084187.2  potassium channel subfamily K member 10 isoform 1

    See identical proteins and their annotated locations for NP_084187.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AC134249, AK031904, AK036066
    Consensus CDS
    CCDS36518.1
    UniProtKB/Swiss-Prot
    A0A1Y7VJZ9, F6YU65, Q8BUW1, Q9CX88
    UniProtKB/TrEMBL
    Q8BZB0
    Related
    ENSMUSP00000152473.2, ENSMUST00000221240.2
    Conserved Domains (1) summary
    pfam07885
    Location:145203
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    98395691..98544472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516259.5XP_006516322.1  potassium channel subfamily K member 10 isoform X4

    Conserved Domains (1) summary
    pfam07885
    Location:152206
    Ion_trans_2; Ion channel
  2. XM_011244181.3XP_011242483.1  potassium channel subfamily K member 10 isoform X1

    See identical proteins and their annotated locations for XP_011242483.1

    UniProtKB/TrEMBL
    Q8BZB0
    Conserved Domains (1) summary
    pfam07885
    Location:135189
    Ion_trans_2; Ion channel
  3. XM_006516257.4XP_006516320.1  potassium channel subfamily K member 10 isoform X2

    UniProtKB/TrEMBL
    Q8BZB0
    Conserved Domains (1) summary
    pfam07885
    Location:94152
    Ion_trans_2; Ion channel
  4. XM_036157621.1XP_036013514.1  potassium channel subfamily K member 10 isoform X2

    UniProtKB/TrEMBL
    Q8BZB0
    Conserved Domains (1) summary
    pfam07885
    Location:94152
    Ion_trans_2; Ion channel
  5. XM_036157622.1XP_036013515.1  potassium channel subfamily K member 10 isoform X3

    Conserved Domains (1) summary
    pfam07885
    Location:148206
    Ion_trans_2; Ion channel