TRPC2 transient receptor potential cation channel subfamily C member 2 (pseudogene) [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRPC2provided by HGNC
Official Full Name: transient receptor potential cation channel subfamily C member 2 (pseudogene)provided by HGNC
Primary source: HGNC:HGNC:12334
See related: Ensembl:ENSG00000290962 AllianceGenome:HGNC:12334
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable diacylglycerol binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to act upstream of or within several processes, including female courtship behavior; inter-male aggressive behavior; and mating behavior, sex discrimination. Predicted to be located in dendrite membrane and endomembrane system. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in bone marrow (RPKM 1.0), lung (RPKM 0.4) and 11 other tissues See more
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Genomic context

Location:: 11p15.4

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (3626460..3637559)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (3671928..3682997)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (3647690..3658789)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

human TRPC2 gene is compared to mouse isoforms of TRPC2: it may never have been an active gene because of incomplete ancestral duplication or loss of chromosomal sequences
Title: The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus.
Relaxed selective pressure in primate evolution.
Title: Relaxed selective pressure on an essential component of pheromone transduction in primate evolution.
the mammalian genome codes for seven TRPCs of which TRPC2 is the largest with the most restricted pattern of expression and has several alternatively spliced variants--{REVIEW}
Title: TRPC2: molecular biology and functional importance.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC152292P2 (e-PCR)
- UniSTS:271216

PMC152292P3 (e-PCR)
- UniSTS:271217

PMC21939P1 (e-PCR)
- UniSTS:272078

Other Names

transient receptor potential channel 2 (pseudogene)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.