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TRPC1 transient receptor potential cation channel subfamily C member 1 [ Homo sapiens (human) ]

Gene ID: 7220, updated on 1-Aug-2020

Summary

Official Symbol
TRPC1provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily C member 1provided by HGNC
Primary source
HGNC:HGNC:12333
See related
Ensembl:ENSG00000144935 MIM:602343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRP1; HTRP-1
Summary
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 3.9) and 22 other tissues See more
Orthologs

Genomic context

See TRPC1 in Genome Data Viewer
Location:
3q23
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (142724034..142807888)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142443266..142526730)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374136 Neighboring gene plastin 1 Neighboring gene RN7SK pseudogene 25 Neighboring gene RNA, U7 small nuclear 47 pseudogene Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene ribosomal protein L8 pseudogene 3 Neighboring gene uncharacterized LOC100507389

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat PI3K/Akt, TRPC, and GSK3 beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133334, MGC133335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium channel activity TAS
Traceable Author Statement
more info
PubMed 
cation channel activity EXP
Inferred from Experiment
more info
PubMed 
inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol 1,4,5 trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
manganese ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
melanin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
short transient receptor potential channel 1
Names
TRP-1
capacitative calcium channel protein Trp1
transient receptor potential canonical 1
transient receptor protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030369.1 RefSeqGene

    Range
    4611..88465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001251845.2NP_001238774.1  short transient receptor potential channel 1 isoform 1

    See identical proteins and their annotated locations for NP_001238774.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC072028, AI280444, BC112338, X89066
    Consensus CDS
    CCDS58856.1
    UniProtKB/Swiss-Prot
    P48995
    Related
    ENSP00000419313.1, ENST00000476941.6
    Conserved Domains (1) summary
    cl26777
    Location:48774
    TRP_2; Transient receptor ion channel II
  2. NM_003304.4NP_003295.1  short transient receptor potential channel 1 isoform 2

    See identical proteins and their annotated locations for NP_003295.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BX331349, DB185459, X89066
    Consensus CDS
    CCDS3126.1
    UniProtKB/Swiss-Prot
    P48995
    Related
    ENSP00000273482.6, ENST00000273482.10
    Conserved Domains (2) summary
    sd00045
    Location:83117
    ANK; ANK repeat [structural motif]
    cl26777
    Location:48740
    TRP_2; Transient receptor ion channel II

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    142724034..142807888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247739.2XP_005247796.1  short transient receptor potential channel 1 isoform X3

    See identical proteins and their annotated locations for XP_005247796.1

    Conserved Domains (1) summary
    cl26777
    Location:25642
    TRP_2; Transient receptor ion channel II
  2. XM_005247738.4XP_005247795.1  short transient receptor potential channel 1 isoform X2

    See identical proteins and their annotated locations for XP_005247795.1

    Conserved Domains (1) summary
    cl26777
    Location:14676
    TRP_2; Transient receptor ion channel II
  3. XM_017007121.2XP_016862610.1  short transient receptor potential channel 1 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:1118
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:2713
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:132190
    TRP_2; Transient receptor ion channel II

RNA

  1. XR_241506.4 RNA Sequence

  2. XR_001740246.1 RNA Sequence

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