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RXFP2 relaxin family peptide receptor 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 721969, updated on 17-Dec-2025
Official Symbol
RXFP2provided by VGNC
Official Full Name
relaxin family peptide receptor 2provided by VGNC
Primary source
VGNC:VGNC:77039
See related
Ensembl:ENSMMUG00000003898
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
LGR8
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See RXFP2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 17 NC_133422.1 (11509010..11579685)
103 previous assembly Mmul_10 (GCF_003339765.1) 17 NC_041770.1 (10722739..10793554)

Chromosome 17 - NC_133422.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC144336247 Neighboring gene beta 3-glucosyltransferase Neighboring gene uncharacterized LOC106994211 Neighboring gene uncharacterized LOC106994212 Neighboring gene elongation factor 1-delta pseudogene Neighboring gene uncharacterized LOC144336253

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques. Hanna CB, et al. Reprod Biol Endocrinol, 2010 Dec 7. PMID 21138583, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The presence of INSL3 and its receptor in the ovary implies a potential role of the ligand-receptor pair in female reproduction in nonhuman primates.
    Title: Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
relaxin receptor 2
Names
G protein coupled receptor affecting testicular descent
leucine-rich repeat G-protein-coupled receptor 8
relaxin/insulin like family peptide receptor 2
NP_001182686.1

Length

  • 754

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195757.1 → NP_001182686.1  relaxin receptor 2

    See identical proteins and their annotated locations for NP_001182686.1

    Status: PROVISIONAL

    Source sequence(s)
    GU326354
    UniProtKB/TrEMBL
    A0A5F7ZR58, D3JXK7
    Related
    ENSMMUP00000068114.1, ENSMMUT00000092629.1
    Conserved Domains (6) summary
    cd00112
    Location:45 → 80
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00116
    Location:155 → 303
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:139 → 162
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:305 → 341
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:161 → 221
    LRR_8; Leucine rich repeat
    cl21561
    Location:424 → 628
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133422.1 Reference T2T-MMU8v2.0

    Range
    11509010..11579685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials