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Nsun4 NOL1/NOP2/Sun domain family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 72181, updated on 11-Apr-2024

Summary

Official Symbol
Nsun4provided by MGI
Official Full Name
NOL1/NOP2/Sun domain family, member 4provided by MGI
Primary source
MGI:MGI:1919431
See related
Ensembl:ENSMUSG00000028706 AllianceGenome:MGI:1919431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Shtap; 2310010O12Rik; 2810405F18Rik
Summary
Enables small ribosomal subunit rRNA binding activity. Involved in mature ribosome assembly; positive regulation of mitochondrial translation; and rRNA methylation. Located in mitochondrion. Is expressed in several structures, including branchial arch; central nervous system; limb bud; neural ectoderm; and sensory organ. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 57.2) and heart adult (RPKM 3.5) See more
Orthologs
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Genomic context

Location:
4 D1; 4 53.1 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115890202..115911076, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116033002..116053879, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38492 Neighboring gene STARR-seq mESC enhancer starr_11131 Neighboring gene fatty acid amide hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E3503 Neighboring gene STARR-positive B cell enhancer ABC_E4647 Neighboring gene predicted gene 12854 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene leucine rich repeat containing 41 Neighboring gene predicted gene, 52704

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables rRNA (cytosine-C5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables rRNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables small ribosomal subunit rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA (cytidine-5-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in cytosolic ribosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
putative methyltransferase NSUN4
Names
5-methylcytosine tRNA methyltransferase NSUN4
sperm head and tail associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369075.1NP_001356004.1  putative methyltransferase NSUN4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AL627105
    Conserved Domains (1) summary
    COG0144
    Location:103274
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  2. NM_001369076.1NP_001356005.1  putative methyltransferase NSUN4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AL627105
    Conserved Domains (1) summary
    COG0144
    Location:103274
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  3. NM_028142.5NP_082418.1  putative methyltransferase NSUN4 isoform a

    See identical proteins and their annotated locations for NP_082418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL627105
    Consensus CDS
    CCDS18502.1
    UniProtKB/Swiss-Prot
    Q9CZ57, Q9D7F0
    Related
    ENSMUSP00000030475.2, ENSMUST00000030475.3
    Conserved Domains (1) summary
    cl17173
    Location:163322
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115890202..115911076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003955016.2 RNA Sequence

  2. XR_376358.4 RNA Sequence