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Dhx36 DEAH-box helicase 36 [ Mus musculus (house mouse) ]

Gene ID: 72162, updated on 9-May-2024

Summary

Official Symbol
Dhx36provided by MGI
Official Full Name
DEAH-box helicase 36provided by MGI
Primary source
MGI:MGI:1919412
See related
Ensembl:ENSMUSG00000027770 AllianceGenome:MGI:1919412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RHAU; Ddx36; mKIAA1488; 2810407E23Rik
Summary
Enables DNA helicase activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in several processes, including G-quadruplex DNA unwinding; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytosol. Is expressed in heart and telencephalon. Orthologous to human DHX36 (DEAH-box helicase 36). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 15.7), CNS E14 (RPKM 15.6) and 24 other tissues See more
Orthologs
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Genomic context

See Dhx36 in Genome Data Viewer
Location:
3 E1; 3 29.97 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (62375436..62414464, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (62468015..62507034, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07811 Neighboring gene predicted gene, 57711 Neighboring gene STARR-seq mESC enhancer starr_07812 Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene predicted gene, 33923 Neighboring gene STARR-seq mESC enhancer starr_07813 Neighboring gene STARR-seq mESC enhancer starr_07814 Neighboring gene STARR-seq mESC enhancer starr_07815 Neighboring gene G protein-coupled receptor 149 Neighboring gene STARR-seq mESC enhancer starr_07816 Neighboring gene STARR-seq mESC enhancer starr_07817 Neighboring gene STARR-seq mESC enhancer starr_07818 Neighboring gene mediator of cell motility 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA helicase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables G-quadruplex DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables G-quadruplex RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-quadruplex RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in G-quadruplex DNA unwinding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G-quadruplex DNA unwinding ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA secondary structure unwinding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to arsenite ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardioblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular mRNA localization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myeloid dendritic cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in telomerase RNA stabilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent DNA/RNA helicase DHX36
Names
ATP-dependent RNA helicase DHX36
DEAD/H box polypeptide 36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
DEAH box protein 36
MLE-like protein 1
RNA helicase associated with AU-rich element ARE
probable ATP-dependent RNA helicase DHX36
NP_082412.2
XP_036019241.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028136.3NP_082412.2  ATP-dependent DNA/RNA helicase DHX36

    See identical proteins and their annotated locations for NP_082412.2

    Status: VALIDATED

    Source sequence(s)
    AC114424
    Consensus CDS
    CCDS17379.1
    UniProtKB/Swiss-Prot
    G3X8Y4, Q6ZPP7, Q8VHK9, Q9CSE8
    UniProtKB/TrEMBL
    B2RQS6
    Related
    ENSMUSP00000029336.5, ENSMUST00000029336.6
    Conserved Domains (1) summary
    COG1643
    Location:188894
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_190643.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114424

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    62375436..62414464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163348.1XP_036019241.1  ATP-dependent DNA/RNA helicase DHX36 isoform X1

    Conserved Domains (1) summary
    COG1643
    Location:41617
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_004941402.1 RNA Sequence

  2. XR_004941401.1 RNA Sequence

  3. XR_004941403.1 RNA Sequence