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Zfp157 zinc finger protein 157 [ Mus musculus (house mouse) ]

Gene ID: 72154, updated on 8-Dec-2022

Summary

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Official Symbol
Zfp157provided by MGI
Official Full Name
zinc finger protein 157provided by MGI
Primary source
MGI:MGI:1919404
See related
Ensembl:ENSMUSG00000036898 AllianceGenome:MGI:1919404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Roma; mszf12; mszf23-1; 2610020C11Rik; A630094N24Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within lung alveolus development; mammary gland morphogenesis; and regulation of cell fate commitment. Is expressed in several structures, including central nervous system; genitourinary system; gut; integumental system; and limb. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 5.4), CNS E14 (RPKM 5.4) and 22 other tissues See more
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Genomic context

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See Zfp157 in Genome Data Viewer
Location:
5; 5 G2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138439721..138459162)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138441458..138460900)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10874 Neighboring gene cytochrome P450, family 3, subfamily a, member 61, pseudogene 1 Neighboring gene predicted gene, 25525 Neighboring gene mortality factor 4 like 1 pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability. Ho TLF, et al. Cell Rep, 2016 Apr 26. PMID 27149840, Free PMC Article
  2. The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin. Oliver CH, et al. Genesis, 2013 Mar. PMID 23315963
  3. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Oliver CH, et al. Genes Dev, 2012 May 15. PMID 22588720, Free PMC Article
  4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  5. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study explores the role of Zfp157 in alveologenesis and reveals that this transcriptional regulator controls the balance of luminal populations and is a critical mediator of Gata-3 signaling.
    Title: The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mammary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within regulation of cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 157

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028130.3 → NP_082406.2  zinc finger protein 157

    See identical proteins and their annotated locations for NP_082406.2

    Status: VALIDATED

    Source sequence(s)
    AI789072, BC059261
    Consensus CDS
    CCDS39345.1
    UniProtKB/TrEMBL
    Q6PCM4
    Related
    ENSMUSP00000083018.6, ENSMUST00000085856.12
    Conserved Domains (6) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:181 → 535
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:381 → 401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:435 → 457
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:366 → 388
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138439721..138459162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165513.1 → XP_036021406.1  zinc finger protein 157 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:88 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288 → 308
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006504625.3 → XP_006504688.1  zinc finger protein 157 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:19 → 79
    KRAB; krueppel associated box
    COG5048
    Location:196 → 550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:396 → 416
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_036165512.1 → XP_036021405.1  zinc finger protein 157 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:88 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288 → 308
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036165510.1 → XP_036021403.1  zinc finger protein 157 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:88 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288 → 308
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_006504626.5 → XP_006504689.1  zinc finger protein 157 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:88 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288 → 308
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036165511.1 → XP_036021404.1  zinc finger protein 157 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:88 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288 → 308
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_036165515.1 → XP_036021408.1  zinc finger protein 157 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:68 → 396
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_006504627.4 → XP_006504690.1  zinc finger protein 157 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:68 → 396
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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