U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adpgk ADP-dependent glucokinase [ Mus musculus (house mouse) ]

Gene ID: 72141, updated on 5-Jan-2023

Summary

Official Symbol
Adpgkprovided by MGI
Official Full Name
ADP-dependent glucokinaseprovided by MGI
Primary source
MGI:MGI:1919391
See related
Ensembl:ENSMUSG00000025236 AllianceGenome:MGI:1919391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adp-gk; 2610017G09Rik
Summary
Enables ADP-specific glucokinase activity. Acts upstream of or within glucose metabolic process. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum. Is expressed in axial musculature and orbito-sphenoid. Orthologous to human ADPGK (ADP dependent glucokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 16.1), limb E14.5 (RPKM 15.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Adpgk in Genome Data Viewer
Location:
9; 9 B
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59198855..59223483)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59291572..59316200)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33053 Neighboring gene predicted gene, 39345 Neighboring gene Bardet-Biedl syndrome 4 (human) Neighboring gene ariadne RBR E3 ubiquitin protein ligase 1 Neighboring gene ribosomal protein S11, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP-specific glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ADP-specific glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ADP-specific glucokinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ADP-dependent glucokinase
Names
ATP-dependent glucokinase
NP_001346211.1
NP_082397.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359282.1NP_001346211.1  ADP-dependent glucokinase isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant (1), encodes a protein (isoform 2) that is one amino acid shorter, compared to isoform 1.
    Source sequence(s)
    BC094657, CT025587
    Consensus CDS
    CCDS90583.1
    UniProtKB/TrEMBL
    A0A0R4J064
    Related
    ENSMUSP00000026266.9, ENSMUST00000026266.9
    Conserved Domains (1) summary
    cd01938
    Location:60491
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
  2. NM_028121.2NP_082397.1  ADP-dependent glucokinase isoform 1 precursor

    See identical proteins and their annotated locations for NP_082397.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK011434, AK048904, BC094657
    Consensus CDS
    CCDS23248.1
    UniProtKB/Swiss-Prot
    Q8VDL4
    UniProtKB/TrEMBL
    A0A1L1SSF2
    Related
    ENSMUSP00000149882.2, ENSMUST00000217570.2
    Conserved Domains (1) summary
    cd01938
    Location:60492
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    59198855..59223483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)