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Tpx2 TPX2, microtubule-associated [ Mus musculus (house mouse) ]

Gene ID: 72119, updated on 8-Feb-2024

Summary

Official Symbol
Tpx2provided by MGI
Official Full Name
TPX2, microtubule-associatedprovided by MGI
Primary source
MGI:MGI:1919369
See related
Ensembl:ENSMUSG00000027469 AllianceGenome:MGI:1919369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIL2; p100; REPP86; 2610005B21Rik
Summary
Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in mitotic spindle assembly and regulation of mitotic spindle organization. Located in axon hillock and spindle. Is expressed in nephrogenic zone. Orthologous to human TPX2 (TPX2 microtubule nucleation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 33.6), liver E14 (RPKM 29.8) and 10 other tissues See more
Orthologs
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Genomic context

See Tpx2 in Genome Data Viewer
Location:
2 H1; 2 75.41 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152689859..152737241)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152847964..152895321)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 32057 Neighboring gene cytochrome c oxidase subunit 4I2 Neighboring gene STARR-seq mESC enhancer starr_06077 Neighboring gene BCL2-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152614671-152614780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152615325-152615529 Neighboring gene STARR-seq mESC enhancer starr_06078 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152620177-152620625 Neighboring gene STARR-seq mESC enhancer starr_06080 Neighboring gene predicted gene, 32211 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152642211-152642412 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152642094-152642203 Neighboring gene STARR-seq mESC enhancer starr_06082 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152651505-152651806 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152656963-152657264 Neighboring gene STARR-positive B cell enhancer ABC_E514 Neighboring gene microRNA 5622 Neighboring gene STARR-seq mESC enhancer starr_06083 Neighboring gene STARR-positive B cell enhancer ABC_E10154 Neighboring gene myosin, light polypeptide kinase 2, skeletal muscle Neighboring gene forkhead box S1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables importin-alpha family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spindle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in aster ISO
Inferred from Sequence Orthology
more info
 
located_in axon hillock IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
targeting protein for Xklp2
Names
TPX2, microtubule-associated protein homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141975.1NP_001135447.1  targeting protein for Xklp2

    See identical proteins and their annotated locations for NP_001135447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK090101, AK167030, BC060619, CJ163921
    Consensus CDS
    CCDS16900.1
    UniProtKB/Swiss-Prot
    A2APB8, Q3U500, Q6P9S6
    UniProtKB/TrEMBL
    Q8BTJ3
    Related
    ENSMUSP00000136457.2, ENSMUST00000178997.8
    Conserved Domains (3) summary
    pfam06886
    Location:661717
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  2. NM_001141976.1NP_001135448.1  targeting protein for Xklp2

    See identical proteins and their annotated locations for NP_001135448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK167030, BC060619, BU148033, CJ163921
    Consensus CDS
    CCDS16900.1
    UniProtKB/Swiss-Prot
    A2APB8, Q3U500, Q6P9S6
    UniProtKB/TrEMBL
    Q8BTJ3
    Conserved Domains (3) summary
    pfam06886
    Location:661717
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  3. NM_001141977.1NP_001135449.1  targeting protein for Xklp2

    See identical proteins and their annotated locations for NP_001135449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AK167030, BC060619, CA558942, CJ163921
    Consensus CDS
    CCDS16900.1
    UniProtKB/Swiss-Prot
    A2APB8, Q3U500, Q6P9S6
    UniProtKB/TrEMBL
    Q8BTJ3
    Related
    ENSMUSP00000128888.2, ENSMUST00000164120.8
    Conserved Domains (3) summary
    pfam06886
    Location:661717
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  4. NM_001141978.1NP_001135450.1  targeting protein for Xklp2

    See identical proteins and their annotated locations for NP_001135450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK090101, AK167030, BC060619, CJ163921
    Consensus CDS
    CCDS16900.1
    UniProtKB/Swiss-Prot
    A2APB8, Q3U500, Q6P9S6
    UniProtKB/TrEMBL
    Q8BTJ3
    Related
    ENSMUSP00000105441.2, ENSMUST00000109816.8
    Conserved Domains (3) summary
    pfam06886
    Location:661717
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  5. NM_028109.4NP_082385.3  targeting protein for Xklp2

    See identical proteins and their annotated locations for NP_082385.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK167030, BC060619, CJ163921
    Consensus CDS
    CCDS16900.1
    UniProtKB/Swiss-Prot
    A2APB8, Q3U500, Q6P9S6
    UniProtKB/TrEMBL
    Q8BTJ3
    Related
    ENSMUSP00000028969.9, ENSMUST00000028969.9
    Conserved Domains (3) summary
    pfam06886
    Location:661717
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152689859..152737241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500213.3XP_006500276.1  targeting protein for Xklp2 isoform X1

    See identical proteins and their annotated locations for XP_006500276.1

    UniProtKB/Swiss-Prot
    A2APB8, Q3U500, Q6P9S6
    UniProtKB/TrEMBL
    Q8BTJ3
    Conserved Domains (3) summary
    pfam06886
    Location:661717
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  2. XM_006500215.3XP_006500278.1  targeting protein for Xklp2 isoform X1

    See identical proteins and their annotated locations for XP_006500278.1

    UniProtKB/Swiss-Prot
    A2APB8, Q3U500, Q6P9S6
    UniProtKB/TrEMBL
    Q8BTJ3
    Conserved Domains (3) summary
    pfam06886
    Location:661717
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  3. XM_006500214.3XP_006500277.1  targeting protein for Xklp2 isoform X1

    See identical proteins and their annotated locations for XP_006500277.1

    UniProtKB/Swiss-Prot
    A2APB8, Q3U500, Q6P9S6
    UniProtKB/TrEMBL
    Q8BTJ3
    Conserved Domains (3) summary
    pfam06886
    Location:661717
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein