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Adck1 aarF domain containing kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 72113, updated on 30-Apr-2024

Summary

Official Symbol
Adck1provided by MGI
Official Full Name
aarF domain containing kinase 1provided by MGI
Primary source
MGI:MGI:1919363
See related
Ensembl:ENSMUSG00000021044 AllianceGenome:MGI:1919363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610005A10Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in lipid homeostasis; mitochondrion organization; and regulation of mitochondrion organization. Predicted to act upstream of or within phosphorylation. Located in mitochondrion. Orthologous to human ADCK1 (aarF domain containing kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 9.4), adrenal adult (RPKM 8.6) and 28 other tissues See more
Orthologs
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Genomic context

See Adck1 in Genome Data Viewer
Location:
12 D2- D3; 12 42.55 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (88327264..88428496)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (88360494..88461726)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3200001D21 gene Neighboring gene RIKEN cDNA 4930473H19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:89667228-89667411 Neighboring gene STARR-seq mESC enhancer starr_32906 Neighboring gene CDK5 and Abl enzyme substrate 2 pseudogene Neighboring gene ubiquitin specific peptidase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32907 Neighboring gene STARR-seq mESC enhancer starr_32908 Neighboring gene uncharacterized protein C1orf103 homolog Neighboring gene STARR-seq mESC enhancer starr_32909 Neighboring gene STARR-seq mESC enhancer starr_32910 Neighboring gene STARR-seq mESC enhancer starr_32911 Neighboring gene neurexin III Neighboring gene STARR-seq mESC enhancer starr_32912 Neighboring gene VISTA enhancer mm296 Neighboring gene predicted gene, 40537

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cristae formation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aarF domain-containing protein kinase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277296.1NP_001264225.1  aarF domain-containing protein kinase 1 isoform a

    See identical proteins and their annotated locations for NP_001264225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2 and 3, encodes the longest isoform (a).
    Source sequence(s)
    AK011310, AK050868, BB042684, BB868931, BY242507
    Consensus CDS
    CCDS26087.1
    UniProtKB/Swiss-Prot
    Q3UKJ2, Q9D0L4
    Related
    ENSMUSP00000152821.2, ENSMUST00000222695.2
    Conserved Domains (1) summary
    cd13969
    Location:117369
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  2. NM_001277297.1NP_001264226.1  aarF domain-containing protein kinase 1 isoform a

    See identical proteins and their annotated locations for NP_001264226.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longest isoform (a).
    Source sequence(s)
    AK011310, AK050868, BB042684, BY242507
    Consensus CDS
    CCDS26087.1
    UniProtKB/Swiss-Prot
    Q3UKJ2, Q9D0L4
    Related
    ENSMUSP00000098724.3, ENSMUST00000101165.9
    Conserved Domains (1) summary
    cd13969
    Location:117369
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  3. NM_001361598.1NP_001348527.1  aarF domain-containing protein kinase 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    CT030260, CT485612
    Conserved Domains (1) summary
    cd13969
    Location:84311
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  4. NM_001361599.1NP_001348528.1  aarF domain-containing protein kinase 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    CT030260, CT485612
    Conserved Domains (1) summary
    cd13969
    Location:73248
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  5. NM_001361600.1NP_001348529.1  aarF domain-containing protein kinase 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BB850741, CT030260, CT485612
    Conserved Domains (1) summary
    cd13969
    Location:1243
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  6. NM_001361601.1NP_001348530.1  aarF domain-containing protein kinase 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    BY198896, CT030260, CT485612
    Conserved Domains (1) summary
    cd13969
    Location:15190
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  7. NM_028105.4NP_082381.1  aarF domain-containing protein kinase 1 isoform a

    See identical proteins and their annotated locations for NP_082381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes the longest isoform (a).
    Source sequence(s)
    AK050868, BB042684, BY291967
    Consensus CDS
    CCDS26087.1
    UniProtKB/Swiss-Prot
    Q3UKJ2, Q9D0L4
    Related
    ENSMUSP00000127254.2, ENSMUST00000166940.3
    Conserved Domains (1) summary
    cd13969
    Location:117369
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    88327264..88428496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516246.4XP_006516309.1  aarF domain-containing protein kinase 1 isoform X4

    Conserved Domains (1) summary
    cd13969
    Location:74301
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  2. XM_030246934.2XP_030102794.1  aarF domain-containing protein kinase 1 isoform X1

    Conserved Domains (1) summary
    cd13969
    Location:127379
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  3. XM_006516251.4XP_006516314.1  aarF domain-containing protein kinase 1 isoform X8

    See identical proteins and their annotated locations for XP_006516314.1

    Conserved Domains (1) summary
    cd13969
    Location:1243
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  4. XM_006516245.5XP_006516308.1  aarF domain-containing protein kinase 1 isoform X2

    Conserved Domains (1) summary
    cd13969
    Location:76328
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  5. XM_006516248.5XP_006516311.1  aarF domain-containing protein kinase 1 isoform X7

    Conserved Domains (1) summary
    cd13969
    Location:66295
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  6. XM_030246938.2XP_030102798.1  aarF domain-containing protein kinase 1 isoform X4

    Conserved Domains (1) summary
    cd13969
    Location:74301
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  7. XM_030246935.1XP_030102795.1  aarF domain-containing protein kinase 1 isoform X1

    Conserved Domains (1) summary
    cd13969
    Location:127379
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  8. XM_030246933.2XP_030102793.1  aarF domain-containing protein kinase 1 isoform X1

    Conserved Domains (1) summary
    cd13969
    Location:127379
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  9. XM_030246937.2XP_030102797.1  aarF domain-containing protein kinase 1 isoform X3

    Conserved Domains (1) summary
    cd13969
    Location:84311
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  10. XM_030246939.2XP_030102799.1  aarF domain-containing protein kinase 1 isoform X8

    Conserved Domains (1) summary
    cd13969
    Location:1243
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  11. XM_030246936.2XP_030102796.1  aarF domain-containing protein kinase 1 isoform X2

    Conserved Domains (1) summary
    cd13969
    Location:76328
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  12. XM_006516252.5XP_006516315.1  aarF domain-containing protein kinase 1 isoform X8

    See identical proteins and their annotated locations for XP_006516315.1

    Conserved Domains (1) summary
    cd13969
    Location:1243
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  13. XM_030246940.2XP_030102800.1  aarF domain-containing protein kinase 1 isoform X9

    Conserved Domains (1) summary
    cd13969
    Location:1177
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  14. XM_036157619.1XP_036013512.1  aarF domain-containing protein kinase 1 isoform X5

    Conserved Domains (1) summary
    cd13969
    Location:45297
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  15. XM_036157620.1XP_036013513.1  aarF domain-containing protein kinase 1 isoform X6

    Related
    ENSMUST00000223538.2
    Conserved Domains (1) summary
    cd13969
    Location:68297
    ADCK1-like; aarF domain containing kinase 1 and similar proteins