Anks4b ankyrin repeat and sterile alpha motif domain containing 4B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anks4bprovided by MGI
Official Full Name: ankyrin repeat and sterile alpha motif domain containing 4Bprovided by MGI
Primary source: MGI:MGI:1919324
See related: Ensembl:ENSMUSG00000030909 AllianceGenome:MGI:1919324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Harp; 2010013E14Rik
Summary: Acts upstream of or within response to endoplasmic reticulum stress. Located in several cellular components, including brush border; endoplasmic reticulum membrane; and microvillus. Is expressed in alimentary system; cochlea epithelium; genitourinary system; liver; and lung epithelium. Orthologous to human ANKS4B (ankyrin repeat and sterile alpha motif domain containing 4B). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in large intestine adult (RPKM 15.4), liver adult (RPKM 8.9) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: 7 F2; 7 64.45 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (119773081..119782939)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (120173858..120183716)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anks4b is a HNF4alpha target gene that regulates endoplasmic reticulum stress in beta-cells by interacting with GRP78, thus suggesting that HNF4alpha is involved in maintenance of the ER.
Title: Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
Harp + harmonin constitute a scaffolding complex to facilitate signal transduction in epithelia.
Title: Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488863

AI956809 (e-PCR)
- UniSTS:179637

Anks4b (e-PCR), detects polymorphism
- UniSTS:548033

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in brush border assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in brush border assembly	IEA Inferred from Electronic Annotation more info
involved_in brush border assembly	ISO Inferred from Sequence Orthology more info
involved_in brush border assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in protein localization to microvillus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to microvillus	IEA Inferred from Electronic Annotation more info
involved_in protein localization to microvillus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to microvillus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane bounded cell projection	IEA Inferred from Electronic Annotation more info
is_active_in stereocilia ankle link	IEA Inferred from Electronic Annotation more info
is_active_in stereocilia ankle link	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin repeat and SAM domain-containing protein 4B

Names: harmonin-interacting ankyrin repeat-containing protein; harmonin-interacting ankyrin-repeat containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028085.2 → NP_082361.2 ankyrin repeat and SAM domain-containing protein 4B

See identical proteins and their annotated locations for NP_082361.2

Status: VALIDATED

Source sequence(s)

AI956809, AK008229, BC118013, BY106969

Consensus CDS

CCDS21793.1

UniProtKB/Swiss-Prot

Q148R3, Q8K3X6, Q9D8A5

Related

ENSMUSP00000033201.6, ENSMUST00000033201.7

Conserved Domains (5) summary

cd09587
Location:350 → 416

SAM_HARP; SAM domain of HARP subfamily

smart00454
Location:357 → 410

SAM; Sterile alpha motif

cd00204
Location:3 → 117

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:6 → 95

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:3 → 29

ANK; ANK repeat [structural motif]