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Cnot2 CCR4-NOT transcription complex, subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 72068, updated on 8-Jan-2023

Summary

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Official Symbol
Cnot2provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 2provided by MGI
Primary source
MGI:MGI:1919318
See related
Ensembl:ENSMUSG00000020166 AllianceGenome:MGI:1919318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600016M12Rik; 2810470K03Rik
Summary
Predicted to enable transcription corepressor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Involved in regulation of stem cell population maintenance and trophectodermal cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including 1st branchial arch; brain; genitourinary system; hemolymphoid system gland; and intestine. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.3), CNS E11.5 (RPKM 10.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Cnot2 in Genome Data Viewer
Location:
10; 10 D2
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116321065..116418891, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (116485160..116581900, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4 Neighboring gene predicted gene, 53634 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 2 Neighboring gene predicted gene, 31593 Neighboring gene RIKEN cDNA 5330438D12 gene Neighboring gene predicted gene, 46203 Neighboring gene predicted gene, 26579

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells. Kamon M, et al. Stem Cells Dev, 2014 Sep 15. PMID 24200330, Free PMC Article
  2. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Zheng X, et al. Stem Cells, 2012 May. PMID 22367759, Free PMC Article
  3. Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development. Chen C, et al. Biochem Biophys Res Commun, 2011 Jul 29. PMID 21741365
  4. Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium. Zhang X, et al. iScience, 2021 Oct 22. PMID 34622152, Free PMC Article
  5. Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Suzuki T, et al. Development, 2019 Feb 15. PMID 30733279, Free PMC Article

See all (38) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
    Title: Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
  2. Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs.
    Title: Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC115808

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of cytoplasmic mRNA processing body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of stem cell population maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in trophectodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 2
Names
CCR4-associated factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037846.3 → NP_001032935.2  CCR4-NOT transcription complex subunit 2 isoform a

    See identical proteins and their annotated locations for NP_001032935.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AK078121, BB353467, BC065171, BM245866
    Consensus CDS
    CCDS36064.1
    UniProtKB/Swiss-Prot
    Q8C5L3, Q9D0P1
    UniProtKB/TrEMBL
    A0A8C6GRU9
    Related
    ENSMUSP00000100902.2, ENSMUST00000105267.8
    Conserved Domains (1) summary
    pfam04153
    Location:396 → 519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  2. NM_001037847.2 → NP_001032936.2  CCR4-NOT transcription complex subunit 2 isoform d

    See identical proteins and their annotated locations for NP_001032936.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 5' coding region and uses an upstream translation start codon, compared to variant 1. The resulting isoform (d) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK078121, BB353467, BC065171, BM245866
    UniProtKB/Swiss-Prot
    Q8C5L3
    UniProtKB/TrEMBL
    A0A1S6GWJ6, A0A8C6GQ60
    Conserved Domains (1) summary
    pfam04153
    Location:406 → 529
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  3. NM_001037848.3 → NP_001032937.1  CCR4-NOT transcription complex subunit 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR, lacks several exons in the 3' coding region, and includes an alternate terminal exon, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC139376, AK078121, BC065171, BG067916
    Consensus CDS
    CCDS36065.1
    UniProtKB/Swiss-Prot
    Q8C5L3
    UniProtKB/TrEMBL
    A0A8C6GQT5, H7BWX6
    Related
    ENSMUSP00000020374.6, ENSMUST00000020374.6

  4. NM_001359247.1 → NP_001346176.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, BC065171, CD578905
    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  5. NM_001359248.1 → NP_001346177.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, BC065171, CX562783
    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  6. NM_001359249.1 → NP_001346178.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK011231, AK078121, BB353467, BC043133, BC065171, CD578905
    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  7. NM_001359250.1 → NP_001346179.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, BC065171, CX562783
    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  8. NM_001359251.1 → NP_001346180.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK011231, AK078121, BB353467, BC043133, BC065171, CD578905
    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  9. NM_001359252.1 → NP_001346181.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, BC065171, CD578905, CX562783
    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  10. NM_001359253.1 → NP_001346182.1  CCR4-NOT transcription complex subunit 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, CX562783
    Conserved Domains (1) summary
    pfam04153
    Location:206 → 329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  11. NM_001359563.1 → NP_001346492.1  CCR4-NOT transcription complex subunit 2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC139376, AI428917, AK011231, BC065171
    Consensus CDS
    CCDS88089.1
    Related
    ENSMUSP00000100900.2, ENSMUST00000105265.8
    Conserved Domains (1) summary
    pfam04153
    Location:311 → 434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  12. NM_028082.2 → NP_082358.2  CCR4-NOT transcription complex subunit 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform 1.
    Source sequence(s)
    AK078121, BB345568, BC065171, BC090624
    Consensus CDS
    CCDS24185.2
    UniProtKB/Swiss-Prot
    Q8C5L3
    UniProtKB/TrEMBL
    A0A8C6GRY7, E9Q027, Q5CZY5
    Related
    ENSMUSP00000132315.2, ENSMUST00000168036.8
    Conserved Domains (1) summary
    pfam04153
    Location:355 → 478
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    116321065..116418891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514188.5 → XP_006514251.1  CCR4-NOT transcription complex subunit 2 isoform X8

    UniProtKB/TrEMBL
    A0A8C6GRV8
    Conserved Domains (1) summary
    pfam04153
    Location:259 → 382
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  2. XM_006514186.4 → XP_006514249.1  CCR4-NOT transcription complex subunit 2 isoform X6

    Conserved Domains (1) summary
    pfam04153
    Location:269 → 392
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  3. XM_030245299.2 → XP_030101159.1  CCR4-NOT transcription complex subunit 2 isoform X5

    Conserved Domains (1) summary
    pfam04153
    Location:311 → 434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  4. XM_006514189.3 → XP_006514252.1  CCR4-NOT transcription complex subunit 2 isoform X10

    Conserved Domains (1) summary
    pfam04153
    Location:218 → 341
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  5. XM_006514190.3 → XP_006514253.1  CCR4-NOT transcription complex subunit 2 isoform X11

    See identical proteins and their annotated locations for XP_006514253.1

    Conserved Domains (1) summary
    pfam04153
    Location:206 → 329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  6. XM_006514183.3 → XP_006514246.1  CCR4-NOT transcription complex subunit 2 isoform X5

    See identical proteins and their annotated locations for XP_006514246.1

    UniProtKB/Swiss-Prot
    Q8C5L3
    Conserved Domains (1) summary
    pfam04153
    Location:311 → 434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  7. XM_030245302.1 → XP_030101162.1  CCR4-NOT transcription complex subunit 2 isoform X11

    Conserved Domains (1) summary
    pfam04153
    Location:206 → 329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  8. XM_036156035.1 → XP_036011928.1  CCR4-NOT transcription complex subunit 2 isoform X5

    Conserved Domains (1) summary
    pfam04153
    Location:311 → 434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  9. XM_017314111.1 → XP_017169600.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250 → 373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  10. XM_036156036.1 → XP_036011929.1  CCR4-NOT transcription complex subunit 2 isoform X5

    Conserved Domains (1) summary
    pfam04153
    Location:311 → 434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  11. XM_030245301.1 → XP_030101161.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250 → 373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  12. XM_030245300.1 → XP_030101160.1  CCR4-NOT transcription complex subunit 2 isoform X7

    Conserved Domains (1) summary
    pfam04153
    Location:228 → 351
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  13. XM_036156038.1 → XP_036011931.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250 → 373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  14. XM_036156039.1 → XP_036011932.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250 → 373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  15. XM_006514184.3 → XP_006514247.1  CCR4-NOT transcription complex subunit 2 isoform X5

    See identical proteins and their annotated locations for XP_006514247.1

    UniProtKB/Swiss-Prot
    Q8C5L3
    Conserved Domains (1) summary
    pfam04153
    Location:311 → 434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  16. XM_036156040.1 → XP_036011933.1  CCR4-NOT transcription complex subunit 2 isoform X11

    Conserved Domains (1) summary
    pfam04153
    Location:206 → 329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  17. XM_006514191.2 → XP_006514254.1  CCR4-NOT transcription complex subunit 2 isoform X11

    See identical proteins and their annotated locations for XP_006514254.1

    Conserved Domains (1) summary
    pfam04153
    Location:206 → 329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  18. XM_036156037.1 → XP_036011930.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250 → 373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  19. XM_006514174.4 → XP_006514237.1  CCR4-NOT transcription complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006514237.1

    Conserved Domains (1) summary
    pfam04153
    Location:365 → 488
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  20. XM_030245297.2 → XP_030101157.1  CCR4-NOT transcription complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  21. XM_006514181.3 → XP_006514244.1  CCR4-NOT transcription complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_006514244.1

    UniProtKB/Swiss-Prot
    Q8C5L3
    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  22. XM_017314107.2 → XP_017169596.1  CCR4-NOT transcription complex subunit 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8C5L3
    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  23. XM_006514182.4 → XP_006514245.1  CCR4-NOT transcription complex subunit 2 isoform X4

    Conserved Domains (1) summary
    pfam04153
    Location:376 → 499
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  24. XM_036156034.1 → XP_036011927.1  CCR4-NOT transcription complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  25. XM_036156033.1 → XP_036011926.1  CCR4-NOT transcription complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C6GSR6
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  26. XM_030245296.2 → XP_030101156.1  CCR4-NOT transcription complex subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9D0P1
    UniProtKB/TrEMBL
    A0A8C6GRU9
    Conserved Domains (1) summary
    pfam04153
    Location:396 → 519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  27. XM_006514175.5 → XP_006514238.1  CCR4-NOT transcription complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006514238.1

    UniProtKB/Swiss-Prot
    Q8C5L3, Q9D0P1
    UniProtKB/TrEMBL
    A0A8C6GRU9
    Conserved Domains (1) summary
    pfam04153
    Location:396 → 519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  28. XM_036156041.1 → XP_036011934.1  CCR4-NOT transcription complex subunit 2 isoform X12

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C5L3.2 GenPept UniProtKB/Swiss-Prot:Q8C5L3

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