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Cnot2 CCR4-NOT transcription complex, subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 72068, updated on 11-Apr-2024

Summary

Official Symbol
Cnot2provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 2provided by MGI
Primary source
MGI:MGI:1919318
See related
Ensembl:ENSMUSG00000020166 AllianceGenome:MGI:1919318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600016M12Rik; 2810470K03Rik
Summary
Predicted to enable transcription corepressor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Involved in regulation of stem cell population maintenance and trophectodermal cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including 1st branchial arch; brain; genitourinary system; hemolymphoid system gland; and intestine. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.3), CNS E11.5 (RPKM 10.3) and 27 other tissues See more
Orthologs
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Genomic context

See Cnot2 in Genome Data Viewer
Location:
10 D2; 10 64.76 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116321065..116418891, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (116485160..116581900, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4 Neighboring gene predicted gene, 53634 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 2 Neighboring gene STARR-positive B cell enhancer ABC_E2965 Neighboring gene STARR-positive B cell enhancer ABC_E5184 Neighboring gene STARR-seq mESC enhancer starr_27957 Neighboring gene predicted gene, 31593 Neighboring gene STARR-positive B cell enhancer ABC_E6924 Neighboring gene STARR-seq mESC enhancer starr_27959 Neighboring gene STARR-positive B cell enhancer mm9_chr10:116001983-116002283 Neighboring gene STARR-positive B cell enhancer ABC_E9805 Neighboring gene RIKEN cDNA 5330438D12 gene Neighboring gene STARR-positive B cell enhancer ABC_E6925 Neighboring gene STARR-seq mESC enhancer starr_27960 Neighboring gene STARR-seq mESC enhancer starr_27961 Neighboring gene predicted gene, 46203 Neighboring gene STARR-seq mESC enhancer starr_27962 Neighboring gene predicted gene, 26579

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC115808

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
 
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 2
Names
CCR4-associated factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037846.3NP_001032935.2  CCR4-NOT transcription complex subunit 2 isoform a

    See identical proteins and their annotated locations for NP_001032935.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AK078121, BB353467, BC065171, BM245866
    Consensus CDS
    CCDS36064.1
    UniProtKB/Swiss-Prot
    Q3UE39, Q80YA5, Q8C5L3, Q9D0P1
    UniProtKB/TrEMBL
    Q3TIJ0
    Related
    ENSMUSP00000100902.2, ENSMUST00000105267.8
    Conserved Domains (1) summary
    pfam04153
    Location:396519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  2. NM_001037847.2NP_001032936.2  CCR4-NOT transcription complex subunit 2 isoform d

    See identical proteins and their annotated locations for NP_001032936.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 5' coding region and uses an upstream translation start codon, compared to variant 1. The resulting isoform (d) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK078121, BB353467, BC065171, BM245866
    UniProtKB/TrEMBL
    A0A1S6GWJ6, Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:406529
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  3. NM_001037848.3NP_001032937.1  CCR4-NOT transcription complex subunit 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR, lacks several exons in the 3' coding region, and includes an alternate terminal exon, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC139376, AK078121, BC065171, BG067916
    Consensus CDS
    CCDS36065.1
    UniProtKB/TrEMBL
    H7BWX6
    Related
    ENSMUSP00000020374.6, ENSMUST00000020374.6
  4. NM_001359247.1NP_001346176.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, BC065171, CD578905
    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  5. NM_001359248.1NP_001346177.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, BC065171, CX562783
    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  6. NM_001359249.1NP_001346178.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK011231, AK078121, BB353467, BC043133, BC065171, CD578905
    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  7. NM_001359250.1NP_001346179.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, BC065171, CX562783
    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  8. NM_001359251.1NP_001346180.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK011231, AK078121, BB353467, BC043133, BC065171, CD578905
    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  9. NM_001359252.1NP_001346181.1  CCR4-NOT transcription complex subunit 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, BC065171, CD578905, CX562783
    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  10. NM_001359253.1NP_001346182.1  CCR4-NOT transcription complex subunit 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC139376, AK078121, BB353467, BC043133, CX562783
    Conserved Domains (1) summary
    pfam04153
    Location:206329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  11. NM_001359563.1NP_001346492.1  CCR4-NOT transcription complex subunit 2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC139376, AI428917, AK011231, BC065171
    Consensus CDS
    CCDS88089.1
    UniProtKB/TrEMBL
    Q5CZY5
    Related
    ENSMUSP00000100900.2, ENSMUST00000105265.8
    Conserved Domains (1) summary
    pfam04153
    Location:311434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  12. NM_028082.2NP_082358.2  CCR4-NOT transcription complex subunit 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform 1.
    Source sequence(s)
    AK078121, BB345568, BC065171, BC090624
    Consensus CDS
    CCDS24185.2
    UniProtKB/TrEMBL
    E9Q027, Q5CZY5
    Related
    ENSMUSP00000132315.2, ENSMUST00000168036.8
    Conserved Domains (1) summary
    pfam04153
    Location:355478
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    116321065..116418891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514188.5XP_006514251.1  CCR4-NOT transcription complex subunit 2 isoform X8

    Conserved Domains (1) summary
    pfam04153
    Location:259382
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  2. XM_006514186.4XP_006514249.1  CCR4-NOT transcription complex subunit 2 isoform X6

    Conserved Domains (1) summary
    pfam04153
    Location:269392
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  3. XM_030245299.2XP_030101159.1  CCR4-NOT transcription complex subunit 2 isoform X5

    UniProtKB/TrEMBL
    Q5CZY5
    Conserved Domains (1) summary
    pfam04153
    Location:311434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  4. XM_006514189.3XP_006514252.1  CCR4-NOT transcription complex subunit 2 isoform X10

    Conserved Domains (1) summary
    pfam04153
    Location:218341
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  5. XM_006514190.3XP_006514253.1  CCR4-NOT transcription complex subunit 2 isoform X11

    See identical proteins and their annotated locations for XP_006514253.1

    Conserved Domains (1) summary
    pfam04153
    Location:206329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  6. XM_006514183.3XP_006514246.1  CCR4-NOT transcription complex subunit 2 isoform X5

    See identical proteins and their annotated locations for XP_006514246.1

    UniProtKB/TrEMBL
    Q5CZY5
    Conserved Domains (1) summary
    pfam04153
    Location:311434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  7. XM_030245302.1XP_030101162.1  CCR4-NOT transcription complex subunit 2 isoform X11

    Conserved Domains (1) summary
    pfam04153
    Location:206329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  8. XM_036156035.1XP_036011928.1  CCR4-NOT transcription complex subunit 2 isoform X5

    UniProtKB/TrEMBL
    Q5CZY5
    Conserved Domains (1) summary
    pfam04153
    Location:311434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  9. XM_017314111.1XP_017169600.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  10. XM_036156036.1XP_036011929.1  CCR4-NOT transcription complex subunit 2 isoform X5

    UniProtKB/TrEMBL
    Q5CZY5
    Conserved Domains (1) summary
    pfam04153
    Location:311434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  11. XM_030245301.1XP_030101161.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  12. XM_030245300.1XP_030101160.1  CCR4-NOT transcription complex subunit 2 isoform X7

    Conserved Domains (1) summary
    pfam04153
    Location:228351
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  13. XM_036156038.1XP_036011931.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  14. XM_036156039.1XP_036011932.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  15. XM_006514184.3XP_006514247.1  CCR4-NOT transcription complex subunit 2 isoform X5

    See identical proteins and their annotated locations for XP_006514247.1

    UniProtKB/TrEMBL
    Q5CZY5
    Conserved Domains (1) summary
    pfam04153
    Location:311434
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  16. XM_036156040.1XP_036011933.1  CCR4-NOT transcription complex subunit 2 isoform X11

    Conserved Domains (1) summary
    pfam04153
    Location:206329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  17. XM_006514191.2XP_006514254.1  CCR4-NOT transcription complex subunit 2 isoform X11

    See identical proteins and their annotated locations for XP_006514254.1

    Conserved Domains (1) summary
    pfam04153
    Location:206329
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  18. XM_036156037.1XP_036011930.1  CCR4-NOT transcription complex subunit 2 isoform X9

    Conserved Domains (1) summary
    pfam04153
    Location:250373
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  19. XM_006514174.4XP_006514237.1  CCR4-NOT transcription complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006514237.1

    UniProtKB/TrEMBL
    Q5CZY5
    Conserved Domains (1) summary
    pfam04153
    Location:365488
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  20. XM_030245297.2XP_030101157.1  CCR4-NOT transcription complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  21. XM_006514181.3XP_006514244.1  CCR4-NOT transcription complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_006514244.1

    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  22. XM_017314107.2XP_017169596.1  CCR4-NOT transcription complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  23. XM_006514182.4XP_006514245.1  CCR4-NOT transcription complex subunit 2 isoform X4

    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:376499
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  24. XM_036156034.1XP_036011927.1  CCR4-NOT transcription complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  25. XM_036156033.1XP_036011926.1  CCR4-NOT transcription complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:387510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  26. XM_030245296.2XP_030101156.1  CCR4-NOT transcription complex subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UE39, Q80YA5, Q8C5L3, Q9D0P1
    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:396519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  27. XM_006514175.5XP_006514238.1  CCR4-NOT transcription complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006514238.1

    UniProtKB/Swiss-Prot
    Q3UE39, Q80YA5, Q8C5L3, Q9D0P1
    UniProtKB/TrEMBL
    Q3TIJ0
    Conserved Domains (1) summary
    pfam04153
    Location:396519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  28. XM_036156041.1XP_036011934.1  CCR4-NOT transcription complex subunit 2 isoform X12