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Poglut2 protein O-glucosyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 72050, updated on 8-May-2024

Summary

Official Symbol
Poglut2provided by MGI
Official Full Name
protein O-glucosyltransferase 2provided by MGI
Primary source
MGI:MGI:1919300
See related
Ensembl:ENSMUSG00000026047 AllianceGenome:MGI:1919300
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EP58; Kdel1; Kdelc1; 1810049A15Rik; 5730416C13Rik
Summary
Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Located in endoplasmic reticulum lumen. Is expressed in several structures, including brain; genitourinary system; gut; liver; and spleen. Orthologous to human POGLUT2 (protein O-glucosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 19.9), ovary adult (RPKM 16.5) and 28 other tissues See more
Orthologs
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Genomic context

See Poglut2 in Genome Data Viewer
Location:
1 C1.1; 1 23.54 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (44143060..44158844, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (44106546..44118880, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 168 Neighboring gene testis expressed 30 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:44176158-44176267 Neighboring gene basic, immunoglobulin-like variable motif containing Neighboring gene STARR-positive B cell enhancer mm9_chr1:44204561-44204862 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 5 Neighboring gene methyltransferase like 21E Neighboring gene predicted gene 15833

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables UDP-xylosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein O-glucosyltransferase 2
Names
ER protein 58
ERp58
KDEL (Lys-Asp-Glu-Leu) containing 1
KDEL containing protein 1
KDEL motif-containing protein 1
endoplasmic reticulum resident protein 58
endoplasmic reticulum-resident KDEL protein
protein O-xylosyltransferase POGLUT2
NP_076134.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023645.3NP_076134.1  protein O-glucosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_076134.1

    Status: PROVISIONAL

    Source sequence(s)
    AK035899
    Consensus CDS
    CCDS14929.1
    UniProtKB/Swiss-Prot
    Q8BPU6, Q8C528, Q8R591, Q9D8P1, Q9JHP7
    Related
    ENSMUSP00000064500.3, ENSMUST00000065767.9
    Conserved Domains (3) summary
    smart00557
    Location:29129
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:28127
    Filamin; Filamin/ABP280 repeat
    pfam05686
    Location:151484
    Glyco_transf_90; Glycosyl transferase family 90

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    44143060..44158844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003946583.2 RNA Sequence