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TRIP6 thyroid hormone receptor interactor 6 [ Homo sapiens (human) ]

Gene ID: 7205, updated on 6-Jan-2019

Summary

Official Symbol
TRIP6provided by HGNC
Official Full Name
thyroid hormone receptor interactor 6provided by HGNC
Primary source
HGNC:HGNC:12311
See related
Ensembl:ENSG00000087077 MIM:602933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2
Summary
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 26.6), kidney (RPKM 24.0) and 25 other tissues See more
Orthologs

Genomic context

See TRIP6 in Genome Data Viewer
Location:
7q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (100867328..100873454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100464950..100471076)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene EPH receptor B4 Neighboring gene RNA, 7SL, cytoplasmic 750, pseudogene Neighboring gene solute carrier family 12 member 9 Neighboring gene SLC12A9 antisense RNA 1 Neighboring gene uncharacterized LOC107986830 Neighboring gene microRNA 6875 Neighboring gene serrate, RNA effector molecule Neighboring gene UFM1 specific peptidase 1 (inactive)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3837, MGC4423, MGC10556, MGC10558, MGC29959

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
interleukin-1 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thyroid hormone receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
focal adhesion assembly NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
focal adhesion HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
thyroid receptor-interacting protein 6
Names
OPA-interacting protein 1
TR-interacting protein 6
thyroid hormone receptor interacting protein 6
zyxin related protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003302.3NP_003293.2  thyroid receptor-interacting protein 6

    See identical proteins and their annotated locations for NP_003293.2

    Status: REVIEWED

    Source sequence(s)
    BC004999, BM800083
    Consensus CDS
    CCDS5708.1
    UniProtKB/Swiss-Prot
    Q15654
    Related
    ENSP00000200457.4, ENST00000200457.8
    Conserved Domains (4) summary
    cd09350
    Location:279332
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09357
    Location:399461
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cl02475
    Location:339398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl26464
    Location:8251
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    100867328..100873454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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