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TRIP6 thyroid hormone receptor interactor 6 [ Homo sapiens (human) ]

Gene ID: 7205, updated on 6-Oct-2024

Summary

Official Symbol
TRIP6provided by HGNC
Official Full Name
thyroid hormone receptor interactor 6provided by HGNC
Primary source
HGNC:HGNC:12311
See related
Ensembl:ENSG00000087077 MIM:602933; AllianceGenome:HGNC:12311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2
Summary
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 26.6), kidney (RPKM 24.0) and 25 other tissues See more
Orthologs
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Genomic context

See TRIP6 in Genome Data Viewer
Location:
7q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100867387..100873454)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102107487..102113558)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100465009..100471076)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene EPH receptor B4 Neighboring gene RNA, 7SL, cytoplasmic 750, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100425149-100425944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100426741-100427536 Neighboring gene solute carrier family 12 member 9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100432899-100433818 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100433819-100434738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100434739-100435658 Neighboring gene SLC12A9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100456152-100456652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100456653-100457153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100457811-100458310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100458529-100459030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26390 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100471610-100472274 Neighboring gene microRNA 6875 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100472275-100472939 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100478564-100479401 Neighboring gene serrate, RNA effector molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100483425-100484158 Neighboring gene UFM1 specific peptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC3837, MGC4423, MGC10556, MGC10558, MGC29959

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables interleukin-1 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear thyroid hormone receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
thyroid receptor-interacting protein 6
Names
OPA-interacting protein 1
TR-interacting protein 6
thyroid hormone receptor interacting protein 6
zyxin related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003302.3NP_003293.2  thyroid receptor-interacting protein 6

    See identical proteins and their annotated locations for NP_003293.2

    Status: REVIEWED

    Source sequence(s)
    BC004999, BM800083
    Consensus CDS
    CCDS5708.1
    UniProtKB/Swiss-Prot
    A4D2E7, F2ZC07, F2ZC08, O15170, O15275, Q15654, Q9BTB2, Q9BUE5, Q9BXP3, Q9UNT4
    UniProtKB/TrEMBL
    F2ZC06
    Related
    ENSP00000200457.4, ENST00000200457.9
    Conserved Domains (4) summary
    cd09350
    Location:279332
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09357
    Location:399461
    LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
    cl02475
    Location:339398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl26464
    Location:8251
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100867387..100873454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102107487..102113558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)