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Sulf2 sulfatase 2 [ Mus musculus (house mouse) ]

Gene ID: 72043, updated on 28-Dec-2022

Summary

Official Symbol
Sulf2provided by MGI
Official Full Name
sulfatase 2provided by MGI
Primary source
MGI:MGI:1919293
See related
Ensembl:ENSMUSG00000006800 AllianceGenome:MGI:1919293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSulf-2; mKIAA1247; 2010004N24Rik
Summary
Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including esophagus smooth muscle contraction; glomerular filtration; and skeletal system development. Acts upstream of or within several processes, including liver regeneration; positive regulation of canonical Wnt signaling pathway; and regulation of hepatocyte proliferation. Located in plasma membrane. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 145.3), limb E14.5 (RPKM 91.2) and 21 other tissues See more
Orthologs
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Genomic context

See Sulf2 in Genome Data Viewer
Location:
2; 2 H3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165915819..165997603, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166073899..166155683, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene pluripotency associated transcript 29 Neighboring gene nuclear receptor coactivator 3 Neighboring gene VISTA enhancer mm1346 Neighboring gene predicted gene, 52534 Neighboring gene predicted gene, 30320 Neighboring gene predicted gene, 30536

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N-acetylglucosamine-6-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables N-acetylglucosamine-6-sulfatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables arylsulfatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sulfuric ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bone development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chondrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in esophagus smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glial cell-derived neurotrophic factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glomerular basement membrane development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glomerular filtration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heparan sulfate proteoglycan metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heparan sulfate proteoglycan metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in innervation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within liver regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
extracellular sulfatase Sulf-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252578.1NP_001239507.1  extracellular sulfatase Sulf-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001239507.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 4 all encode the same isoform (1).
    Source sequence(s)
    AL589873
    Consensus CDS
    CCDS17086.1
    UniProtKB/Swiss-Prot
    Q8CFG0, Q9D8E2
    Related
    ENSMUSP00000085405.4, ENSMUST00000088086.4
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533666
    DUF3740; Sulfatase protein
    cl23718
    Location:754803
    ALP_like; alkaline phosphatases and sulfatases
  2. NM_001252579.1NP_001239508.1  extracellular sulfatase Sulf-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate upstream start codon compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK034712, AL589873, CF736722
    UniProtKB/Swiss-Prot
    Q8CFG0
    Conserved Domains (4) summary
    COG3119
    Location:76420
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:573699
    DUF3740; Sulfatase protein
    cd16147
    Location:76418
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:787836
    ALP_like; alkaline phosphatases and sulfatases
  3. NM_001355619.1NP_001342548.1  extracellular sulfatase Sulf-2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (1).
    Source sequence(s)
    AL589873
    Consensus CDS
    CCDS17086.1
    UniProtKB/Swiss-Prot
    Q9D8E2
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533666
    DUF3740; Sulfatase protein
    cl23718
    Location:754803
    ALP_like; alkaline phosphatases and sulfatases
  4. NM_028072.5NP_082348.2  extracellular sulfatase Sulf-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_082348.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (1).
    Source sequence(s)
    AK036685, AL589873, CF736722
    Consensus CDS
    CCDS17086.1
    UniProtKB/Swiss-Prot
    Q8CFG0, Q9D8E2
    Related
    ENSMUSP00000104872.3, ENSMUST00000109249.9
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533666
    DUF3740; Sulfatase protein
    cl23718
    Location:754803
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165915819..165997603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500209.5XP_006500272.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006500272.1

    UniProtKB/Swiss-Prot
    Q8CFG0, Q9D8E2
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533666
    DUF3740; Sulfatase protein
    cl23718
    Location:754803
    ALP_like; alkaline phosphatases and sulfatases
  2. XM_006500211.4XP_006500274.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006500274.1

    UniProtKB/Swiss-Prot
    Q8CFG0, Q9D8E2
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533666
    DUF3740; Sulfatase protein
    cl23718
    Location:754803
    ALP_like; alkaline phosphatases and sulfatases
  3. XM_030252100.1XP_030107960.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9D8E2
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533666
    DUF3740; Sulfatase protein
    cl23718
    Location:754803
    ALP_like; alkaline phosphatases and sulfatases
  4. XM_036162585.1XP_036018478.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9D8E2
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533666
    DUF3740; Sulfatase protein
    cl23718
    Location:754803
    ALP_like; alkaline phosphatases and sulfatases
  5. XM_030252101.1XP_030107961.1  extracellular sulfatase Sulf-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9D8E2
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:533666
    DUF3740; Sulfatase protein
    cl23718
    Location:754803
    ALP_like; alkaline phosphatases and sulfatases