Cotl1 coactosin-like 1 (Dictyostelium) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cotl1provided by MGI
Official Full Name: coactosin-like 1 (Dictyostelium)provided by MGI
Primary source: MGI:MGI:1919292
See related: Ensembl:ENSMUSG00000031827 AllianceGenome:MGI:1919292
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clp; 1810074P22Rik; 2010004C08Rik
Summary: Enables actin binding activity and enzyme binding activity. Involved in defense response to fungus. Predicted to be located in cytosol. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Predicted to colocalize with actin filament. Is expressed in several structures, including brain; gut; renal cortex; sensory organ; and trachea. Orthologous to human COTL1 (coactosin like F-actin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in stomach adult (RPKM 370.0), spleen adult (RPKM 262.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 E1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (120535953..120567318, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (119809214..119840579, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets.
Title: Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets.
Cotl1 overexpression impaired migration of both early- and late-born neurons during mouse corticogenesis. Moreover, Cotl1 overexpression delayed, rather than blocked, neuronal migration in late-born neurons.
Title: Coactosin-like protein 1 inhibits neuronal migration during mouse corticogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PZD00074_allele_9942870 (e-PCR)
- UniSTS:513431

PZD00074_allele_9942871 (e-PCR)
- UniSTS:513431

PZD00074_allele_9942894 (e-PCR)
- UniSTS:513431

Cotl1 (e-PCR), detects polymorphism
- UniSTS:525212

NoName (e-PCR)
- UniSTS:236020

Homology

Homologs of the Cotl1 gene: The Cotl1 gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 484 organisms have orthologs with human gene Cotl1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to fungus	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin filament	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of polarized growth	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: coactosin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.