Tsc22d2 TSC22 domain family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tsc22d2provided by MGI
Official Full Name: TSC22 domain family, member 2provided by MGI
Primary source: MGI:MGI:1919283
See related: Ensembl:ENSMUSG00000027806 AllianceGenome:MGI:1919283
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810043J12Rik; 5530402M19Rik
Summary: Acts upstream of or within response to osmotic stress. Orthologous to human TSC22D2 (TSC22 domain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 7.2), ovary adult (RPKM 5.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3; 3 D

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (58322123..58374208)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (58414702..58466787)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

All TSC22D2 transcripts depend on hypertonicity as the signal for their upregulation and are unresponsive to increases in cell-permeable osmolytes. mRNA stabilization is the mechanism for TSC22D2 upregulation by hyperosmolality.
Title: Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stress.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

BF396992 (e-PCR)
- UniSTS:245901

NoName (e-PCR)
- UniSTS:234692

Homology

Homologs of the Tsc22d2 gene: The Tsc22d2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 469 organisms have orthologs with human gene Tsc22d2
Orthologs

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TSC22 domain family protein 2

Names: TSC22 domain family 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081229.2 → NP_001074698.1 TSC22 domain family protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121794, CF731192

Consensus CDS

CCDS38435.1

UniProtKB/TrEMBL

E9Q7M2

Related

ENSMUSP00000096688.3, ENSMUST00000099090.7

Conserved Domains (1) summary

pfam01166
Location:683 → 739

TSC22; TSC-22/dip/bun family
NM_001347233.1 → NP_001334162.1 TSC22 domain family protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC121794, AK007760

Consensus CDS

CCDS84624.1

UniProtKB/TrEMBL

A0A0G2JFZ4, Q9CVK3

Related

ENSMUSP00000143364.2, ENSMUST00000199164.2