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CCT3 chaperonin containing TCP1 subunit 3 [ Homo sapiens (human) ]

Gene ID: 7203, updated on 6-Jan-2019

Summary

Official Symbol
CCT3provided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 3provided by HGNC
Primary source
HGNC:HGNC:1616
See related
Ensembl:ENSG00000163468 MIM:600114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCTG; PIG48; TRIC5; CCT-gamma; TCP-1-gamma
Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in testis (RPKM 72.7), adrenal (RPKM 56.4) and 25 other tissues See more
Orthologs

Genomic context

See CCT3 in Genome Data Viewer
Location:
1q22
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (156308961..156338415, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156278752..156308206, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glycosylated lysosomal membrane protein Neighboring gene VHL like Neighboring gene TSSK6 activating cochaperone Neighboring gene Rh family B glycoprotein (gene/pseudogene) Neighboring gene chromosome 1 open reading frame 61 Neighboring gene microRNA 9-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with CCT3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body IEA
Inferred from Electronic Annotation
more info
 
chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
chaperonin-containing T-complex TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
zona pellucida receptor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-complex protein 1 subunit gamma
Names
T-complex protein 1, gamma subunit
TCP1 (t-complex-1) ring complex, polypeptide 5
chaperonin containing TCP1, subunit 3 (gamma)
hTRiC5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008800.2NP_001008800.1  T-complex protein 1 subunit gamma isoform c

    See identical proteins and their annotated locations for NP_001008800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AK126400, AK293477, BG476176
    Consensus CDS
    CCDS30888.1
    UniProtKB/Swiss-Prot
    P49368
    UniProtKB/TrEMBL
    B3KX11
    Related
    ENSP00000357242.2, ENST00000368259.6
    Conserved Domains (2) summary
    cd03337
    Location:6487
    TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02344
    Location:6491
    chap_CCT_gamma; T-complex protein 1, gamma subunit
  2. NM_005998.5NP_005989.3  T-complex protein 1 subunit gamma isoform a

    See identical proteins and their annotated locations for NP_005989.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AB208882, AK126400, BG476176
    Consensus CDS
    CCDS1140.2
    UniProtKB/Swiss-Prot
    P49368
    UniProtKB/TrEMBL
    B3KX11, Q59H77
    Related
    ENSP00000295688.3, ENST00000295688.7
    Conserved Domains (2) summary
    cd03337
    Location:6525
    TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02344
    Location:6529
    chap_CCT_gamma; T-complex protein 1, gamma subunit

RNA

  1. NR_036564.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK126400, AK300765, BG476176
    Related
    ENST00000368262.7
  2. NR_036565.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK126400, AK316387, BG476176
    Related
    ENST00000472765.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    156308961..156338415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008883.1: Suppressed sequence

    Description
    NM_001008883.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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