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PGPEP1 pyroglutamyl-peptidase I [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 720200, updated on 10-Feb-2026
Official Symbol
PGPEP1provided by VGNC
Official Full Name
pyroglutamyl-peptidase Iprovided by VGNC
Primary source
VGNC:VGNC:75797
Locus tag
EGK_10328
See related
Ensembl:ENSMMUG00000004406
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PGPEP1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 19 NC_133424.1 (18876320..18905810)
103 previous assembly Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (17883500..17912673)

Chromosome 19 - NC_133424.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC144336875 Neighboring gene uncharacterized LOC144336637 Neighboring gene LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene uncharacterized LOC144336864 Neighboring gene growth differentiation factor 15 Neighboring gene leucine rich repeat containing 25 Neighboring gene single stranded DNA binding protein 4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables pyroglutamyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
pyroglutamyl-peptidase 1
NP_001247617.1
XP_014978792.1
XP_014978795.1
XP_028694382.1
XP_028694384.1
XP_077833070.1
XP_077833071.1
XP_077833072.1
XP_077833073.1
XP_077833074.1
XP_077833075.1
XP_077833076.1
XP_077833077.1
XP_077833078.1
XP_077833079.1
XP_077833080.1
XP_077833081.1
XP_077833082.1
XP_077833083.1
XP_077833084.1
XP_077833085.1
XP_077833087.1
XP_077833088.1
XP_077833089.1
XP_077833090.1
XP_077833091.1
XP_077833092.1
XP_077833093.1
XP_077833095.1
XP_077833096.1
XP_077833097.1
XP_077833098.1
XP_077833099.1
XP_077833100.1
XP_077833101.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260688.1 → NP_001247617.1  pyroglutamyl-peptidase 1

    See identical proteins and their annotated locations for NP_001247617.1

    Status: PROVISIONAL

    Source sequence(s)
    JU473664
    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2
    Related
    ENSMMUP00000061666.1, ENSMMUT00000097338.1
    Conserved Domains (1) summary
    cd00501
    Location:6 → 199
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133424.1 Reference T2T-MMU8v2.0

    Range
    18876320..18905810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_077976946.1 → XP_077833072.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  2. XM_077976945.1 → XP_077833071.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  3. XM_077976948.1 → XP_077833074.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  4. XM_077976949.1 → XP_077833075.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  5. XM_077976954.1 → XP_077833080.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  6. XM_077976953.1 → XP_077833079.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  7. XM_077976962.1 → XP_077833088.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  8. XM_077976956.1 → XP_077833082.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  9. XM_077976955.1 → XP_077833081.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  10. XM_077976957.1 → XP_077833083.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  11. XM_077976959.1 → XP_077833085.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  12. XM_077976963.1 → XP_077833089.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  13. XM_077976947.1 → XP_077833073.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  14. XM_028838551.2 → XP_028694384.1  pyroglutamyl-peptidase 1 isoform X3

    Conserved Domains (1) summary
    cd00501
    Location:6 → 146
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  15. XM_077976969.1 → XP_077833095.1  pyroglutamyl-peptidase 1 isoform X7

    UniProtKB/TrEMBL
    F7GUB6

  16. XM_077976970.1 → XP_077833096.1  pyroglutamyl-peptidase 1 isoform X7

    UniProtKB/TrEMBL
    F7GUB6

  17. XM_077976971.1 → XP_077833097.1  pyroglutamyl-peptidase 1 isoform X7

    UniProtKB/TrEMBL
    F7GUB6

  18. XM_077976975.1 → XP_077833101.1  pyroglutamyl-peptidase 1 isoform X8

    UniProtKB/TrEMBL
    H9F1L3

  19. XM_077976950.1 → XP_077833076.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  20. XM_077976951.1 → XP_077833077.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  21. XM_077976952.1 → XP_077833078.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  22. XM_077976958.1 → XP_077833084.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  23. XM_077976972.1 → XP_077833098.1  pyroglutamyl-peptidase 1 isoform X7

    UniProtKB/TrEMBL
    F7GUB6

  24. XM_015123306.3 → XP_014978792.1  pyroglutamyl-peptidase 1 isoform X7

    UniProtKB/TrEMBL
    F7GUB6
    Related
    ENSMMUP00000005884.2
    Conserved Domains (1) summary
    cl00237
    Location:6 → 92
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  25. XM_077976964.1 → XP_077833090.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  26. XM_077976965.1 → XP_077833091.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  27. XM_077976961.1 → XP_077833087.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  28. XM_077976966.1 → XP_077833092.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F8APU9, A0A8J8Y1J7, G7NNE0, H9Z3F2

  29. XM_015123309.3 → XP_014978795.1  pyroglutamyl-peptidase 1 isoform X6

    Conserved Domains (1) summary
    cd00501
    Location:6 → 146
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  30. XM_077976973.1 → XP_077833099.1  pyroglutamyl-peptidase 1 isoform X7

    UniProtKB/TrEMBL
    F7GUB6

  31. XM_077976974.1 → XP_077833100.1  pyroglutamyl-peptidase 1 isoform X7

    UniProtKB/TrEMBL
    F7GUB6

  32. XM_028838549.2 → XP_028694382.1  pyroglutamyl-peptidase 1 isoform X5

    Conserved Domains (1) summary
    cl00237
    Location:84 → 166
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  33. XM_077976944.1 → XP_077833070.1  pyroglutamyl-peptidase 1 isoform X1

  34. XM_077976967.1 → XP_077833093.1  pyroglutamyl-peptidase 1 isoform X4

Nucleotide Protein
Heading Accession and Version

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