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Cyb5r1 cytochrome b5 reductase 1 [ Mus musculus (house mouse) ]

Gene ID: 72017, updated on 9-Mar-2023

Summary

Official Symbol
Cyb5r1provided by MGI
Official Full Name
cytochrome b5 reductase 1provided by MGI
Primary source
MGI:MGI:1919267
See related
Ensembl:ENSMUSG00000026456 AllianceGenome:MGI:1919267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B5R.1; Nqo3a2; 1500005G05Rik
Summary
Predicted to enable FAD binding activity. Predicted to act upstream of or within sterol biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; nose; respiratory system; and urinary system. Orthologous to human CYB5R1 (cytochrome b5 reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 21.2), ovary adult (RPKM 17.0) and 28 other tissues See more
Orthologs
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Genomic context

See Cyb5r1 in Genome Data Viewer
Location:
1; 1 E4
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134333519..134339476)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134405781..134411738)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53477 Neighboring gene MGAT4 family, member F Neighboring gene adiponectin receptor 1 Neighboring gene kelch-like 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NADH-cytochrome b5 reductase 1
Names
NAD(P)H:quinone oxidoreductase type 3, polypeptide A2
NP_001342062.1
NP_082333.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355133.1NP_001342062.1  NADH-cytochrome b5 reductase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131592
    Conserved Domains (1) summary
    cl26810
    Location:5268
    PLN02252; nitrate reductase [NADPH]
  2. NM_028057.3NP_082333.1  NADH-cytochrome b5 reductase 1 isoform 1

    See identical proteins and their annotated locations for NP_082333.1

    Status: VALIDATED

    Source sequence(s)
    AC131592, AK005159
    Consensus CDS
    CCDS15308.1
    UniProtKB/Swiss-Prot
    Q91W81, Q9DB73
    Related
    ENSMUSP00000027726.8, ENSMUST00000027726.14
    Conserved Domains (2) summary
    cd06183
    Location:49305
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    PTZ00319
    Location:33305
    PTZ00319; NADH-cytochrome B5 reductase; Provisional

RNA

  1. NR_149307.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131592
    Related
    ENSMUST00000154237.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134333519..134339476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)