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TRHR thyrotropin releasing hormone receptor [ Homo sapiens (human) ]

Gene ID: 7201, updated on 1-Jun-2020

Summary

Official Symbol
TRHRprovided by HGNC
Official Full Name
thyrotropin releasing hormone receptorprovided by HGNC
Primary source
HGNC:HGNC:12299
See related
Ensembl:ENSG00000174417 MIM:188545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHNG7; TRH-R
Summary
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TRHR in Genome Data Viewer
Location:
8q23.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (109086585..109121565)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (110099653..110131813)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927413 Neighboring gene uncharacterized LOC107984017 Neighboring gene NudC domain containing 1 Neighboring gene ENY2 transcription and export complex 2 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 7
MedGen: CN262229 OMIM: 618573 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of thyrotropin-releasing hormone receptor (TRHR) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141920

Gene Ontology Provided by GOA

Function Evidence Code Pubs
thyrotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
thyrotropin-releasing hormone receptor
Names
thyroliberin receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017161.1 RefSeqGene

    Range
    4182..39119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003301.7NP_003292.1  thyrotropin-releasing hormone receptor

    See identical proteins and their annotated locations for NP_003292.1

    Status: VALIDATED

    Source sequence(s)
    AC104945
    Consensus CDS
    CCDS6311.1
    UniProtKB/Swiss-Prot
    P34981
    Related
    ENSP00000430711.1, ENST00000518632.1
    Conserved Domains (1) summary
    cd14995
    Location:26331
    7tmA_TRH-R; thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    109086585..109121565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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