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Zfyve19 zinc finger, FYVE domain containing 19 [ Mus musculus (house mouse) ]

Gene ID: 72008, updated on 30-Apr-2024

Summary

Official Symbol
Zfyve19provided by MGI
Official Full Name
zinc finger, FYVE domain containing 19provided by MGI
Primary source
MGI:MGI:1919258
See related
Ensembl:ENSMUSG00000068580 AllianceGenome:MGI:1919258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ANCHR; 1500041L05Rik
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centrosome; cleavage furrow; and midbody. Is expressed in central nervous system and retina. Orthologous to human ZFYVE19 (zinc finger FYVE-type containing 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 16.6), ovary adult (RPKM 13.6) and 28 other tissues See more
Orthologs
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Genomic context

See Zfyve19 in Genome Data Viewer
Location:
2 E5; 2 59.97 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119039088..119047531)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119208607..119217050)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene predicted gene 14137 Neighboring gene STARR-positive B cell enhancer ABC_E5968 Neighboring gene 40S ribosomal protein S6 (Phosphoprotein NP33) Neighboring gene STARR-seq mESC enhancer starr_05476 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:119034498-119034685 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14D Neighboring gene serine protease inhibitor, Kunitz type 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC117612

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in abscission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in abscission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cytokinesis checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cytokinesis checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
abscission/NoCut checkpoint regulator
Names
zinc finger FYVE domain-containing protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164827.1NP_001158299.1  abscission/NoCut checkpoint regulator isoform 2

    See identical proteins and their annotated locations for NP_001158299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL772264, BC099429, CO038937
    Consensus CDS
    CCDS50672.1
    UniProtKB/TrEMBL
    Q4KL52
    Related
    ENSMUSP00000099577.5, ENSMUST00000102519.5
    Conserved Domains (1) summary
    cd15749
    Location:454
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
  2. NM_028054.3NP_082330.2  abscission/NoCut checkpoint regulator isoform 1

    See identical proteins and their annotated locations for NP_082330.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK005386, AL772264, BC099429, CO038937
    Consensus CDS
    CCDS16595.1
    UniProtKB/Swiss-Prot
    A2AV55, Q8VCV7, Q9DAZ9
    Related
    ENSMUSP00000087636.5, ENSMUST00000090174.11
    Conserved Domains (1) summary
    cd15749
    Location:454
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119039088..119047531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252098.1XP_030107958.1  abscission/NoCut checkpoint regulator isoform X5

    Conserved Domains (3) summary
    COG4942
    Location:73258
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd15749
    Location:1752
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:334378
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
  2. XM_011239781.2XP_011238083.1  abscission/NoCut checkpoint regulator isoform X2

    Conserved Domains (3) summary
    COG4942
    Location:75260
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd15749
    Location:454
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:342386
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
  3. XM_006500207.2XP_006500270.1  abscission/NoCut checkpoint regulator isoform X6

    See identical proteins and their annotated locations for XP_006500270.1

    Conserved Domains (3) summary
    PRK11281
    Location:105288
    PRK11281; mechanosensitive channel MscK
    cd15749
    Location:237
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:326370
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
  4. XM_006500204.2XP_006500267.1  abscission/NoCut checkpoint regulator isoform X3

    Conserved Domains (3) summary
    COG4942
    Location:73259
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd15749
    Location:1752
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:341385
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
  5. XM_030252099.2XP_030107959.1  abscission/NoCut checkpoint regulator isoform X8

    Conserved Domains (2) summary
    cd15749
    Location:237
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:319363
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
  6. XM_006500205.3XP_006500268.1  abscission/NoCut checkpoint regulator isoform X4

    Conserved Domains (3) summary
    COG4942
    Location:75261
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd15749
    Location:454
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:337381
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
  7. XM_006500203.4XP_006500266.1  abscission/NoCut checkpoint regulator isoform X1

    Conserved Domains (3) summary
    PRK11281
    Location:122305
    PRK11281; mechanosensitive channel MscK
    cd15749
    Location:454
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:343387
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
  8. XM_036162583.1XP_036018476.1  abscission/NoCut checkpoint regulator isoform X6

    Conserved Domains (3) summary
    PRK11281
    Location:105288
    PRK11281; mechanosensitive channel MscK
    cd15749
    Location:237
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:326370
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
  9. XM_036162584.1XP_036018477.1  abscission/NoCut checkpoint regulator isoform X7

    Conserved Domains (2) summary
    cd15749
    Location:237
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
    cd19817
    Location:325369
    Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins