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Rpusd4 RNA pseudouridylate synthase domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 71989, updated on 5-Mar-2024

Summary

Official Symbol
Rpusd4provided by MGI
Official Full Name
RNA pseudouridylate synthase domain containing 4provided by MGI
Primary source
MGI:MGI:1919239
See related
Ensembl:ENSMUSG00000032044 AllianceGenome:MGI:1919239
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410001E19Rik
Summary
Predicted to enable mitochondrial ribosomal large subunit rRNA binding activity; pseudouridine synthase activity; and tRNA binding activity. Predicted to be involved in enzyme-directed rRNA pseudouridine synthesis; mitochondrial tRNA pseudouridine synthesis; and positive regulation of mitochondrial translation. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Is expressed in genitourinary system. Orthologous to human RPUSD4 (RNA pseudouridine synthase D4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 8.8), limb E14.5 (RPKM 7.0) and 28 other tissues See more
Orthologs
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Genomic context

See Rpusd4 in Genome Data Viewer
Location:
9 A4; 9 20.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35179177..35187253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35267881..35275957)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene signal recognition particle receptor alpha Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene family with sequence similarity 118, member B Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RIKEN cDNA 4933422A05 gene Neighboring gene STARR-positive B cell enhancer ABC_E10539 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene predicted gene, 33838

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitochondrial ribosomal large subunit rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables pseudouridine synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial tRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
 
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pseudouridylate synthase RPUSD4, mitochondrial
Names
RNA pseudouridylate synthase domain-containing protein 4
mitochondrial RNA pseudouridine synthase Rpusd4
NP_082316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028040.2NP_082316.1  pseudouridylate synthase RPUSD4, mitochondrial

    See identical proteins and their annotated locations for NP_082316.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061256
    Consensus CDS
    CCDS22962.1
    UniProtKB/Swiss-Prot
    Q9CWX4
    Related
    ENSMUSP00000034543.5, ENSMUST00000034543.5
    Conserved Domains (2) summary
    TIGR00005
    Location:46347
    rluA_subfam; pseudouridine synthase, RluA family
    cd02869
    Location:106329
    PseudoU_synth_RluCD_like; Pseudouridine synthase, RsuA/RluD family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35179177..35187253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)