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Sars2 seryl-aminoacyl-tRNA synthetase 2 [ Mus musculus (house mouse) ]

Gene ID: 71984, updated on 5-Aug-2022

Summary

Official Symbol
Sars2provided by MGI
Official Full Name
seryl-aminoacyl-tRNA synthetase 2provided by MGI
Primary source
MGI:MGI:1919234
See related
Ensembl:ENSMUSG00000070699 AllianceGenome:MGI:1919234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SerRS; SerRSmt; D7Ertd353e; 2410015F05Rik
Summary
Predicted to enable ATP binding activity; serine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and respiratory system. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 17.6), adrenal adult (RPKM 16.8) and 28 other tissues See more
Orthologs
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Genomic context

See Sars2 in Genome Data Viewer
Location:
7 B1; 7 16.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28441393..28453304)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28741957..28753879)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29527010..29538874)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene F-box protein 17 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in seryl-tRNA aminoacylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
serine--tRNA ligase, mitochondrial
Names
seryl-tRNA synthetase, mitochondrial
seryl-tRNA(Ser/Sec) synthetase
NP_076126.2
XP_006540438.1
XP_006540439.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023637.3NP_076126.2  serine--tRNA ligase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_076126.2

    Status: VALIDATED

    Source sequence(s)
    AK010491, BY649585, CX122368
    Consensus CDS
    CCDS21053.1
    UniProtKB/Swiss-Prot
    Q9CWP1, Q9JJL8
    Related
    ENSMUSP00000092216.5, ENSMUST00000094632.6
    Conserved Domains (3) summary
    PRK05431
    Location:67493
    PRK05431; seryl-tRNA synthetase; Provisional
    cd00770
    Location:185485
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    cl12057
    Location:67172
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28441393..28453304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540375.5XP_006540438.1  serine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK05431
    Location:67253
    PRK05431; seryl-tRNA synthetase; Provisional
  2. XM_006540376.3XP_006540439.1  serine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00268
    Location:1228
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

RNA

  1. XR_003946566.2 RNA Sequence