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Snx10 sorting nexin 10 [ Mus musculus (house mouse) ]

Gene ID: 71982, updated on 9-Sep-2018

Summary

Official Symbol
Snx10provided by MGI
Official Full Name
sorting nexin 10provided by MGI
Primary source
MGI:MGI:1919232
See related
Ensembl:ENSMUSG00000038301 Vega:OTTMUSG00000023330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410004M09Rik
Expression
Broad expression in frontal lobe adult (RPKM 11.5), cortex adult (RPKM 10.9) and 17 other tissues See more
Orthologs

Genomic context

See Snx10 in Genome Data Viewer
Location:
6; 6 B3
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (51523902..51590679)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (51473902..51540669)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 Neighboring gene chromobox 3 Neighboring gene predicted gene, 38811 Neighboring gene src family associated phosphoprotein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
cilium assembly ISO
Inferred from Sequence Orthology
more info
 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome organization ISO
Inferred from Sequence Orthology
more info
 
gastric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
protein localization to cilium ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
ruffle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
tooth eruption IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of endosome membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127348.1NP_001120820.1  sorting nexin-10 isoform a

    See identical proteins and their annotated locations for NP_001120820.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AK028163, AK150878, AK151320, AK166121
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q9CWT3
    UniProtKB/TrEMBL
    Q3UBN7, Q4FJX6
    Related
    ENSMUSP00000136974.1, ENSMUST00000179365.7
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  2. NM_001127349.1NP_001120821.1  sorting nexin-10 isoform a

    See identical proteins and their annotated locations for NP_001120821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AK150878, AK151320
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q9CWT3
    UniProtKB/TrEMBL
    Q3UBN7, Q4FJX6
    Related
    ENSMUSP00000044165.8, OTTMUSP00000027182, ENSMUST00000049152.14, OTTMUST00000056532
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  3. NM_001361576.1NP_001348505.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (a). Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  4. NM_001361577.1NP_001348506.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  5. NM_001361578.1NP_001348507.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  6. NM_001361579.1NP_001348508.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  7. NM_001361580.1NP_001348509.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  8. NM_001361581.1NP_001348510.1  sorting nexin-10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AC153877
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  9. NM_001361582.1NP_001348511.1  sorting nexin-10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC153877
  10. NM_028035.4NP_082311.3  sorting nexin-10 isoform a

    See identical proteins and their annotated locations for NP_082311.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AK028163, AK150878, AK151320
    Consensus CDS
    CCDS20136.1
    UniProtKB/Swiss-Prot
    Q9CWT3
    UniProtKB/TrEMBL
    Q3UBN7, Q4FJX6
    Related
    ENSMUSP00000110082.1, OTTMUSP00000027183, ENSMUST00000114439.7, OTTMUST00000056535
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    51523902..51590679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241475.1XP_011239777.1  sorting nexin-10 isoform X2

    Conserved Domains (1) summary
    cl02563
    Location:169
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. XM_006506653.3XP_006506716.1  sorting nexin-10 isoform X1

    UniProtKB/Swiss-Prot
    Q9CWT3
    UniProtKB/TrEMBL
    Q4FJX6
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  3. XM_017321753.1XP_017177242.1  sorting nexin-10 isoform X1

    UniProtKB/Swiss-Prot
    Q9CWT3
    UniProtKB/TrEMBL
    Q4FJX6
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  4. XM_011241474.1XP_011239776.1  sorting nexin-10 isoform X2

    See identical proteins and their annotated locations for XP_011239776.1

    Conserved Domains (1) summary
    cl02563
    Location:169
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
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