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Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha [ Mus musculus (house mouse) ]

Gene ID: 71978, updated on 7-Apr-2019

Summary

Official Symbol
Ppp2r2aprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B, alphaprovided by MGI
Primary source
MGI:MGI:1919228
See related
Ensembl:ENSMUSG00000022052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1541; 2410004D02Rik
Expression
Ubiquitous expression in adrenal adult (RPKM 26.6), CNS E11.5 (RPKM 11.2) and 27 other tissues See more
Orthologs

Genomic context

See Ppp2r2a in Genome Data Viewer
Location:
14; 14 D1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (67014056..67072471, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (67634508..67691266, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene cold shock domain containing E1, RNA binding pseudogene Neighboring gene BCL2/adenovirus E1B interacting protein 3-like Neighboring gene predicted gene, 30438 Neighboring gene predicted gene, 30806

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1)  1 citation

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
tau protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to morphine IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 
synapse EXP
Inferred from Experiment
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Names
PP2A subunit B isoform B55-alpha
PP2A subunit B isoform PR55-alpha
PP2A subunit B isoform R2-alpha
PP2A subunit B isoform alpha
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
NP_001192117.1
NP_082308.1
XP_011243507.1
XP_017171700.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205188.1NP_001192117.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2

    See identical proteins and their annotated locations for NP_001192117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC165148, AK010380, BC065100, CT030233
    UniProtKB/Swiss-Prot
    Q6P1F6
    UniProtKB/TrEMBL
    Q9CWU3
    Related
    ENSMUSP00000153191.1, ENSMUST00000225380.1
    Conserved Domains (2) summary
    sd00039
    Location:3179
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:29327
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001360033.1NP_001346962.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA185461, AC165148, AK161507, BC065100, CT030233
    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
  3. NM_001360034.1NP_001346963.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165148, AK161507, BC065100, CT030233
    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
  4. NM_028032.3NP_082308.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

    See identical proteins and their annotated locations for NP_082308.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC165148, AK161507, BC065100, CT030233
    Consensus CDS
    CCDS56967.1
    UniProtKB/Swiss-Prot
    Q6P1F6
    UniProtKB/TrEMBL
    Q3TT94
    Related
    ENSMUSP00000086640.5, ENSMUST00000089230.6
    Conserved Domains (2) summary
    COG5170
    Location:7442
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:3179
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    67014056..67072471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245205.2XP_011243507.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1

    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
  2. XM_017316211.1XP_017171700.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1

    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
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