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SELENON selenoprotein N [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 719707, updated on 17-Apr-2026
Official Symbol
SELENONprovided by VGNC
Official Full Name
selenoprotein Nprovided by VGNC
Primary source
VGNC:VGNC:81190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
SEPN1
Summary
This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in the orthologous gene in human are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2016]
Orthologs
all
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Location:
chromosome: 1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 1 NC_133406.1 (215207713..215226099, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (198983824..199002178, complement)

Chromosome 1 - NC_133406.1Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 7 Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene mitochondrial fission regulator 1 like Neighboring gene uncharacterized LOC144335179 Neighboring gene uncharacterized LOC144335191 Neighboring gene uncharacterized LOC144335192 Neighboring gene mannosidase alpha class 1C member 1 Neighboring gene uncharacterized LOC144335181

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons. Howard MT, et al. EMBO J, 2005 Apr 20. PMID 15791204, Free PMC Article
  2. Characterization of mammalian selenoproteomes. Kryukov GV, et al. Science, 2003 May 30. PMID 12775843
  3. Selenoprotein Gene Nomenclature. Gladyshev VN, et al. J Biol Chem, 2016 Nov 11. PMID 27645994, Free PMC Article
  4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
selenoprotein N
Names
selenoprotein N, 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347991.3 → NP_001334920.2  selenoprotein N isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the canonical isoform 1.
    Source sequence(s)
    JBMGST020000001
    Conserved Domains (1) summary
    cl08302
    Location:74 → 113
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001347992.3 → NP_001334921.2  selenoprotein N isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the 3' terminal exon compared to variant 1. The resulting isoform (2) is longer, containing a 4 aa protein segment not found in isoform 1.
    Source sequence(s)
    JBMGST020000001

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133406.1 Reference T2T-MMU8v2.0

    Range
    215207713..215226099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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