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Dus4l dihydrouridine synthase 4-like (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 71916, updated on 16-Mar-2023

Summary

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Official Symbol
Dus4lprovided by MGI
Official Full Name
dihydrouridine synthase 4-like (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1919166
See related
Ensembl:ENSMUSG00000020648 AllianceGenome:MGI:1919166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pp35; 2310069P03Rik; 2700089B10Rik
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to act upstream of or within tRNA processing. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.9), limb E14.5 (RPKM 2.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Dus4l in Genome Data Viewer
Location:
12; 12 A3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31690049..31704834, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31640050..31654866, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 26, member 4 Neighboring gene B cell receptor associated protein 29 Neighboring gene component of oligomeric golgi complex 5 Neighboring gene G protein-coupled receptor 22 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC130363

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables tRNA-dihydrouridine20a synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
NP_082278.1
XP_006515286.1
XP_006515287.1
XP_030102791.1
XP_036013511.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418028.1 → NP_001404957.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119950

  2. NM_028002.3 → NP_082278.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform 1

    See identical proteins and their annotated locations for NP_082278.1

    Status: VALIDATED

    Source sequence(s)
    AC119950
    Consensus CDS
    CCDS25865.1
    UniProtKB/Swiss-Prot
    Q32M08
    UniProtKB/TrEMBL
    A0A0R4J016
    Related
    ENSMUSP00000020977.3, ENSMUST00000020977.4
    Conserved Domains (2) summary
    COG0042
    Location:32 → 311
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd02801
    Location:28 → 257
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RNA

  1. NR_184675.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119950

  2. NR_184676.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119950

  3. NR_184677.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119950

  4. NR_184678.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119950

  5. NR_184679.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119950

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    31690049..31704834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515223.4 → XP_006515286.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X2

    Conserved Domains (1) summary
    cd02801
    Location:38 → 177
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  2. XM_036157618.1 → XP_036013511.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X1

    Conserved Domains (1) summary
    cd02801
    Location:1 → 200
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  3. XM_030246931.2 → XP_030102791.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X3

    Conserved Domains (1) summary
    cd02801
    Location:4 → 136
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  4. XM_006515224.3 → XP_006515287.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X3

    Conserved Domains (1) summary
    cd02801
    Location:4 → 136
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RNA

  1. XR_004937546.1 RNA Sequence

  2. XR_004937545.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32M08.1 GenPept UniProtKB/Swiss-Prot:Q32M08

Gene LinkOut

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