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Antxr2 anthrax toxin receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 71914, updated on 31-Jan-2019

Summary

Official Symbol
Antxr2provided by MGI
Official Full Name
anthrax toxin receptor 2provided by MGI
Primary source
MGI:MGI:1919164
See related
Ensembl:ENSMUSG00000029338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CMG2; CMG-2; cI-35; AW561899; 2310046B19Rik
Expression
Broad expression in heart adult (RPKM 13.0), subcutaneous fat pad adult (RPKM 7.8) and 24 other tissues See more
Orthologs

Genomic context

See Antxr2 in Genome Data Viewer
Location:
5; 5 E3
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (97884688..98030962, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (98313707..98459981, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34029 Neighboring gene predicted gene, 34097 Neighboring gene predicted gene, 34226 Neighboring gene nuclear encoded tRNA lysine 8 (anticodon CTT) Neighboring gene predicted gene 8041

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
toxin transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133738.2NP_598499.1  anthrax toxin receptor 2 precursor

    See identical proteins and their annotated locations for NP_598499.1

    Status: VALIDATED

    Source sequence(s)
    BC076595, BY792979
    Consensus CDS
    CCDS39177.1
    UniProtKB/Swiss-Prot
    Q6DFX2
    UniProtKB/TrEMBL
    Q3TCL6
    Related
    ENSMUSP00000031281.9, ENSMUST00000031281.13
    Conserved Domains (3) summary
    cd01474
    Location:39221
    vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
    pfam05586
    Location:394485
    Ant_C; Anthrax receptor C-terminus region
    pfam05587
    Location:223317
    Anth_Ig; Anthrax receptor extracellular domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    97884688..98030962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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