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Cand1 cullin associated and neddylation disassociated 1 [ Mus musculus (house mouse) ]

Gene ID: 71902, updated on 30-Apr-2024

Summary

Official Symbol
Cand1provided by MGI
Official Full Name
cullin associated and neddylation disassociated 1provided by MGI
Primary source
MGI:MGI:1261820
See related
Ensembl:ENSMUSG00000020114 AllianceGenome:MGI:1261820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tp120a; mKIAA0829; D10Ertd516e; 2310038O07Rik; 6330512O03Rik
Summary
Predicted to enable TBP-class protein binding activity. Predicted to be involved in several processes, including SCF complex assembly; positive regulation of RNA polymerase II transcription preinitiation complex assembly; and protein ubiquitination. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.0), placenta adult (RPKM 11.5) and 28 other tissues See more
Orthologs
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Genomic context

See Cand1 in Genome Data Viewer
Location:
10 D2; 10 67.08 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (119034717..119075960, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (119198812..119240055, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33982 Neighboring gene predicted gene, 34045 Neighboring gene STARR-seq mESC enhancer starr_28037 Neighboring gene STARR-positive B cell enhancer ABC_E3922 Neighboring gene STARR-positive B cell enhancer ABC_E1815 Neighboring gene STARR-seq mESC enhancer starr_28038 Neighboring gene STARR-seq mESC enhancer starr_28039 Neighboring gene STARR-seq mESC enhancer starr_28040 Neighboring gene STARR-seq mESC enhancer starr_28041 Neighboring gene RIKEN cDNA 4930477N07 gene Neighboring gene proteasome (prosome, macropain) subunit, alpha type 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in SCF complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in SCF complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cullin-associated NEDD8-dissociated protein 1
Names
TBP-interacting protein
cullin-associated and neddylation-dissociated protein 1
p120 CAND1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027994.1NP_082270.1  cullin-associated NEDD8-dissociated protein 1

    See identical proteins and their annotated locations for NP_082270.1

    Status: VALIDATED

    Source sequence(s)
    AC160063
    Consensus CDS
    CCDS48701.1
    UniProtKB/Swiss-Prot
    Q6PFR0, Q6ZQ38, Q9CV45
    Related
    ENSMUSP00000020315.7, ENSMUST00000020315.13
    Conserved Domains (4) summary
    cd00020
    Location:650745
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam08623
    Location:10401202
    TIP120; TATA-binding protein interacting (TIP20)
    pfam13513
    Location:149202
    HEAT_EZ; HEAT-like repeat
    sd00044
    Location:817847
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    119034717..119075960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)