U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IRF3 interferon regulatory factor 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 718970, updated on 10-Feb-2026
Official Symbol
IRF3provided by VGNC
Official Full Name
interferon regulatory factor 3provided by VGNC
Primary source
VGNC:VGNC:73761
See related
Ensembl:ENSMMUG00000022735
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See IRF3 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 19 NC_133424.1 (62111905..62118888, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (49629971..49637050, complement)

Chromosome 19 - NC_133424.1Genomic Context describing neighboring genes Neighboring gene RAS related Neighboring gene SR-related CTD associated factor 1 Neighboring gene BCL2 like 12 Neighboring gene protein arginine methyltransferase 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1. Diao F, et al. J Virol, 2023 Apr 27. PMID 37039642, Free PMC Article
  2. Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation. Paulmann D, et al. J Gen Virol, 2008 Jul. PMID 18559929
  3. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, et al. Nat Med, 2008 Oct. PMID 18806803
  4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
    Title: Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
interferon regulatory factor 3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135797.1 → NP_001129269.1  interferon regulatory factor 3

    See identical proteins and their annotated locations for NP_001129269.1

    Status: PROVISIONAL

    Source sequence(s)
    EU204919
    UniProtKB/TrEMBL
    A0A5K1U635, B6CJX6, F6ZMA1
    Conserved Domains (2) summary
    pfam00605
    Location:7 → 110
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:198 → 375
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133424.1 Reference T2T-MMU8v2.0

    Range
    62111905..62118888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_077976687.1 → XP_077832813.1  interferon regulatory factor 3 isoform X7

  2. XM_015124405.3 → XP_014979891.3  interferon regulatory factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A5K1U635, G7NLP6

  3. XM_077976682.1 → XP_077832808.1  interferon regulatory factor 3 isoform X4

  4. XM_028838509.2 → XP_028694342.2  interferon regulatory factor 3 isoform X1

    UniProtKB/TrEMBL
    F7GFL3

  5. XM_077976678.1 → XP_077832804.1  interferon regulatory factor 3 isoform X2

  6. XM_077976686.1 → XP_077832812.1  interferon regulatory factor 3 isoform X7

  7. XM_028838512.2 → XP_028694345.2  interferon regulatory factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A5K1U635, G7NLP6

  8. XM_028838508.2 → XP_028694341.2  interferon regulatory factor 3 isoform X1

    UniProtKB/TrEMBL
    F7GFL3

  9. XM_077976691.1 → XP_077832817.1  interferon regulatory factor 3 isoform X8

  10. XM_077976689.1 → XP_077832815.1  interferon regulatory factor 3 isoform X7

  11. XM_077976690.1 → XP_077832816.1  interferon regulatory factor 3 isoform X8

  12. XM_077976683.1 → XP_077832809.1  interferon regulatory factor 3 isoform X7

  13. XM_077976684.1 → XP_077832810.1  interferon regulatory factor 3 isoform X7

  14. XM_028838516.2 → XP_028694349.2  interferon regulatory factor 3 isoform X6

  15. XM_077976681.1 → XP_077832807.1  interferon regulatory factor 3 isoform X4

  16. XM_015124407.3 → XP_014979893.3  interferon regulatory factor 3 isoform X1

    UniProtKB/TrEMBL
    F7GFL3

  17. XM_077976685.1 → XP_077832811.1  interferon regulatory factor 3 isoform X7

  18. XM_028838511.2 → XP_028694344.2  interferon regulatory factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A5K1U635, G7NLP6

  19. XM_028838507.2 → XP_028694340.2  interferon regulatory factor 3 isoform X1

    UniProtKB/TrEMBL
    F7GFL3

  20. XM_077976680.1 → XP_077832806.1  interferon regulatory factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A5K1U635, G7NLP6

  21. XM_015124406.3 → XP_014979892.3  interferon regulatory factor 3 isoform X5

    UniProtKB/TrEMBL
    A0A5K1U635
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials