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Mad2l2 MAD2 mitotic arrest deficient-like 2 [ Mus musculus (house mouse) ]

Gene ID: 71890, updated on 9-Mar-2023

Summary

Official Symbol
Mad2l2provided by MGI
Official Full Name
MAD2 mitotic arrest deficient-like 2provided by MGI
Primary source
MGI:MGI:1919140
See related
Ensembl:ENSMUSG00000029003 AllianceGenome:MGI:1919140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
REV7; MAD2B; repro22; G1-453-4; 2310033C13Rik
Summary
Predicted to enable JUN kinase binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including negative regulation of cell-cell adhesion mediated by cadherin; regulation of nucleobase-containing compound metabolic process; and regulation of protein metabolic process. Predicted to act upstream of or within DNA repair and cell division. Predicted to be located in cytosol; nucleolus; and spindle. Predicted to be part of anaphase-promoting complex and zeta DNA polymerase complex. Is expressed in several structures, including brain; ganglia; genitourinary system; intestine; and olfactory epithelium. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group V. Orthologous to human MAD2L2 (mitotic arrest deficient 2 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 68.8), CNS E14 (RPKM 17.7) and 21 other tissues See more
Orthologs
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Genomic context

See Mad2l2 in Genome Data Viewer
Location:
4; 4 E2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148214615..148230161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148130158..148145704)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13201 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2, pseudogene Neighboring gene angiotensin II, type I receptor-associated protein Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene microRNA 7022 Neighboring gene F-box protein 6 Neighboring gene F-box protein 44 Neighboring gene F-box protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response, signal transduction resulting in transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by competitive promoter binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair via nonhomologous end joining NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of isotype switching ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in somatic diversification of immunoglobulins involved in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in telomere maintenance in response to DNA damage NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break NAS
Non-traceable Author Statement
more info
PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
part_of zeta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of zeta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitotic spindle assembly checkpoint protein MAD2B
Names
MAD2-like protein 2
mitotic arrest deficient 2-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305420.1NP_001292349.1  mitotic spindle assembly checkpoint protein MAD2B

    See identical proteins and their annotated locations for NP_001292349.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK009587, AL606929, CO043741
    Consensus CDS
    CCDS18932.1
    UniProtKB/Swiss-Prot
    Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A0A6P5PL56, A0A8C6GZ20
    Related
    ENSMUSP00000081146.3, ENSMUST00000084129.9
    Conserved Domains (1) summary
    pfam02301
    Location:18103
    HORMA; HORMA domain
  2. NM_027985.3NP_082261.2  mitotic spindle assembly checkpoint protein MAD2B

    See identical proteins and their annotated locations for NP_082261.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK009587, AK150216, CO043741
    Consensus CDS
    CCDS18932.1
    UniProtKB/Swiss-Prot
    Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A0A6P5PL56, A0A8C6GZ20
    Related
    ENSMUSP00000030860.3, ENSMUST00000030860.9
    Conserved Domains (1) summary
    pfam02301
    Location:18103
    HORMA; HORMA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    148214615..148230161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253789.1XP_030109649.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    UniProtKB/Swiss-Prot
    Q91VP1
    UniProtKB/TrEMBL
    A0A6P5PL56, A0A8C6GZ20
    Conserved Domains (1) summary
    pfam02301
    Location:18103
    HORMA; HORMA domain
  2. XM_006539187.3XP_006539250.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    See identical proteins and their annotated locations for XP_006539250.1

    UniProtKB/Swiss-Prot
    Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A0A6P5PL56, A0A8C6GZ20
    Conserved Domains (1) summary
    pfam02301
    Location:18103
    HORMA; HORMA domain
  3. XM_030253798.2XP_030109658.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  4. XM_006539183.3XP_006539246.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    See identical proteins and their annotated locations for XP_006539246.1

    UniProtKB/Swiss-Prot
    Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A0A6P5PL56, A0A8C6GZ20
    Conserved Domains (1) summary
    pfam02301
    Location:18103
    HORMA; HORMA domain
  5. XM_030253794.2XP_030109654.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  6. XM_006539186.3XP_006539249.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    See identical proteins and their annotated locations for XP_006539249.1

    UniProtKB/Swiss-Prot
    Q91VP1, Q9D752
    UniProtKB/TrEMBL
    A0A6P5PL56, A0A8C6GZ20
    Conserved Domains (1) summary
    pfam02301
    Location:18103
    HORMA; HORMA domain
  7. XM_030253797.2XP_030109657.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  8. XM_030253791.1XP_030109651.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  9. XM_030253788.2XP_030109648.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    UniProtKB/Swiss-Prot
    Q91VP1
    UniProtKB/TrEMBL
    A0A6P5PL56, A0A8C6GZ20
    Conserved Domains (1) summary
    pfam02301
    Location:18103
    HORMA; HORMA domain
  10. XM_006539189.4XP_006539252.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    See identical proteins and their annotated locations for XP_006539252.1

    UniProtKB/TrEMBL
    A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  11. XM_030253795.2XP_030109655.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  12. XM_030253792.2XP_030109652.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  13. XM_030253799.2XP_030109659.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G7
    Related
    ENSMUSP00000101332.2, ENSMUST00000105707.2
    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  14. XM_030253796.1XP_030109656.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

    UniProtKB/TrEMBL
    A2A7G7
    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  15. XM_030253793.2XP_030109653.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  16. XM_006539188.3XP_006539251.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

    See identical proteins and their annotated locations for XP_006539251.1

    Conserved Domains (1) summary
    pfam02301
    Location:18100
    HORMA; HORMA domain
  17. XM_030253790.2XP_030109650.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

    UniProtKB/Swiss-Prot
    Q91VP1
    UniProtKB/TrEMBL
    A0A6P5PL56, A0A8C6GZ20
    Related
    ENSMUSP00000122774.2, ENSMUST00000132698.8
    Conserved Domains (1) summary
    pfam02301
    Location:18103
    HORMA; HORMA domain

RNA

  1. XR_004941965.1 RNA Sequence