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Fam83d family with sequence similarity 83, member D [ Mus musculus (house mouse) ]

Gene ID: 71878, updated on 7-Apr-2025

Summary

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Official Symbol
Fam83dprovided by MGI
Official Full Name
family with sequence similarity 83, member Dprovided by MGI
Primary source
MGI:MGI:1919128
See related
Ensembl:ENSMUSG00000027654 AllianceGenome:MGI:1919128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310007D09Rik
Summary
Predicted to enable kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Predicted to be located in cytoplasm; intercellular bridge; and mitotic spindle. Predicted to be active in cytosol and mitotic spindle pole. Is expressed in cerebral cortex ventricular layer; diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory epithelium; and telencephalon ventricular layer. Orthologous to human FAM83D (family with sequence similarity 83 member D). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in stomach adult (RPKM 15.0), colon adult (RPKM 14.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Fam83d in Genome Data Viewer
Location:
2 H1; 2 78.73 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158610011..158628557)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158768099..158786637)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10158 Neighboring gene ARP5 actin-related protein 5 Neighboring gene microRNA 3474 Neighboring gene STARR-positive B cell enhancer ABC_E7879 Neighboring gene STARR-positive B cell enhancer mm9_chr2:158499319-158499620 Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene STARR-positive B cell enhancer ABC_E2650 Neighboring gene STARR-positive B cell enhancer ABC_E7880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:158548828-158549026 Neighboring gene STARR-positive B cell enhancer ABC_E2056 Neighboring gene STARR-positive B cell enhancer ABC_E7881 Neighboring gene STARR-positive B cell enhancer ABC_E416 Neighboring gene STARR-seq mESC enhancer starr_06234 Neighboring gene DEAH-box helicase 35 Neighboring gene STARR-seq mESC enhancer starr_06235 Neighboring gene STARR-positive B cell enhancer ABC_E6010 Neighboring gene STARR-seq mESC enhancer starr_06237 Neighboring gene predicted gene, 38630 Neighboring gene STARR-seq mESC enhancer starr_06238

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TAF4b transcription networks regulating early oocyte differentiation. Gura MA, et al. Development, 2022 Feb 1. PMID 35043944, Free PMC Article
  2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC92947

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinesin binding IEA
Inferred from Electronic Annotation
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell cycle G1/S phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle G1/S phase transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM83D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418738.1 → NP_001405667.1  protein FAM83D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663077, AL669910

  2. NM_027975.3 → NP_082251.2  protein FAM83D isoform 1

    See identical proteins and their annotated locations for NP_082251.2

    Status: VALIDATED

    Source sequence(s)
    AL663077, AL669910
    Consensus CDS
    CCDS50788.1
    UniProtKB/Swiss-Prot
    A2AC91, Q3TXE0, Q6P396, Q8BYC0, Q9D7I8
    Related
    ENSMUSP00000029183.3, ENSMUST00000029183.3
    Conserved Domains (2) summary
    pfam13091
    Location:149 → 284
    PLDc_2; PLD-like domain
    cl15239
    Location:21 → 291
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RNA

  1. NR_184811.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663077, AL669910

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    158610011..158628557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162579.1 → XP_036018472.1  protein FAM83D isoform X1

    Conserved Domains (1) summary
    cl15239
    Location:13 → 92
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7I8.1 GenPept UniProtKB/Swiss-Prot:Q9D7I8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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