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Zswim2 zinc finger SWIM-type containing 2 [ Mus musculus (house mouse) ]

Gene ID: 71861, updated on 15-Nov-2022

Summary

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Official Symbol
Zswim2provided by MGI
Official Full Name
zinc finger SWIM-type containing 2provided by MGI
Primary source
MGI:MGI:1919111
See related
Ensembl:ENSMUSG00000034552 AllianceGenome:MGI:1919111
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MEX; 1700025P14Rik; 4933437F18Rik
Summary
Enables protein self-association and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Orthologous to human ZSWIM2 (zinc finger SWIM-type containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 15.6) See more
Orthologs
human all
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Genomic context

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See Zswim2 in Genome Data Viewer
Location:
2; 2 D
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (83745423..83771596, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (83915079..83941226, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene integrin alpha V Neighboring gene DNA methyltransferase 3-like, pseudogene 1 Neighboring gene family with sequence similarity 171, member B Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice. Nozawa K, et al. BMC Biol, 2022 Jul 13. PMID 35831855, Free PMC Article
  2. MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Nishito Y, et al. Biochem J, 2006 Jun 15. PMID 16522193, Free PMC Article
  3. An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance. Li N, et al. Oncogenesis, 2019 Feb 19. PMID 30783098, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Zswim2
Names
MEKK1-related protein X
RING-type E3 ubiquitin transferase Zswim2
ZZ-type zinc finger-containing protein 2
zinc finger SWIM domain-containing protein 2
zinc finger, SWIM domain containing 2
NP_082240.1
XP_036018470.1
XP_036018471.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027964.2 → NP_082240.1  E3 ubiquitin-protein ligase Zswim2

    See identical proteins and their annotated locations for NP_082240.1

    Status: PROVISIONAL

    Source sequence(s)
    AK006367
    Consensus CDS
    CCDS16183.1
    UniProtKB/Swiss-Prot
    Q9D9X6
    UniProtKB/TrEMBL
    Q0VB10
    Related
    ENSMUSP00000044913.2, ENSMUST00000038223.8
    Conserved Domains (3) summary
    pfam04434
    Location:54 → 86
    SWIM; SWIM zinc finger
    pfam13639
    Location:343 → 386
    zf-RING_2; Ring finger domain
    cl00295
    Location:233 → 271
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    83745423..83771596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162577.1 → XP_036018470.1  E3 ubiquitin-protein ligase Zswim2 isoform X1

    Related
    ENSMUSP00000119439.2, ENSMUST00000152829.2
    Conserved Domains (4) summary
    pfam04434
    Location:54 → 86
    SWIM; SWIM zinc finger
    cd16494
    Location:144 → 202
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
    cl00295
    Location:233 → 271
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cl17238
    Location:343 → 365
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_036162578.1 → XP_036018471.1  E3 ubiquitin-protein ligase Zswim2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9X6.1 GenPept UniProtKB/Swiss-Prot:Q9D9X6

Gene LinkOut

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