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TRAF2 TNF receptor associated factor 2 [ Homo sapiens (human) ]

Gene ID: 7186, updated on 25-Oct-2020

Summary

Official Symbol
TRAF2provided by HGNC
Official Full Name
TNF receptor associated factor 2provided by HGNC
Primary source
HGNC:HGNC:12032
See related
Ensembl:ENSG00000127191 MIM:601895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAP; TRAP3; RNF117; MGC:45012
Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 3.4), spleen (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See TRAF2 in Genome Data Viewer
Location:
9q34.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (136881933..136926615)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139776341..139821853)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene MAM domain containing 4 Neighboring gene endothelial differentiation related factor 1 Neighboring gene uncharacterized LOC105376326 Neighboring gene microRNA 4479 Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene complement C8 gamma chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages PubMed
nef HIV-1 Nef interacts with TRAF2, TRAF5, and TRAF6 proteins via its C-terminal region (residues 55-206) in monocyte-derived macrophages PubMed
nef The acidic cluster AQEEEE (residues 64-69) of HIV-1 Nef binds to the residues R393, R403, F447, S454, and F456 of TRAF2 PubMed
nef TRAF2 and TRAF6 proteins are required for the HIV-1 Nef-induced tyrosine phosphorylation of STAT1 and STAT2 proteins PubMed
Vpr vpr HIV-1 Vpr-mediated CASP8 (caspase 8) activation is mediated by TRAF-2 in THP-1 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CD40 receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
mitogen-activated protein kinase kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
sphingolipid binding IDA
Inferred from Direct Assay
more info
PubMed 
thioesterase binding IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
activation of NF-kappaB-inducing kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
cellular protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to nitric oxide IEA
Inferred from Electronic Annotation
more info
 
death-inducing signaling complex assembly TAS
Traceable Author Statement
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
Traceable Author Statement
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
negative regulation of glial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death TAS
Traceable Author Statement
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
programmed necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein autoubiquitination TAS
Traceable Author Statement
more info
PubMed 
protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
regulation of immunoglobulin secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
response to endoplasmic reticulum stress NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
CD40 receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
IRE1-TRAF2-ASK1 complex IDA
Inferred from Direct Assay
more info
PubMed 
TRAF2-GSTP1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tumor necrosis factor receptor superfamily complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TNF receptor-associated factor 2
Names
E3 ubiquitin-protein ligase TRAF2
RING-type E3 ubiquitin transferase TRAF2
tumor necrosis factor type 2 receptor associated protein 3
NP_066961.2
XP_011517276.1
XP_011517278.1
XP_011517279.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021138.4NP_066961.2  TNF receptor-associated factor 2

    See identical proteins and their annotated locations for NP_066961.2

    Status: REVIEWED

    Source sequence(s)
    BC043492, BC064662
    Consensus CDS
    CCDS7013.1
    UniProtKB/Swiss-Prot
    Q12933
    UniProtKB/TrEMBL
    A0A024R8H5
    Related
    ENSP00000247668.2, ENST00000247668.7
    Conserved Domains (5) summary
    cd03778
    Location:334497
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178235
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:267329
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    cl28410
    Location:28157
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    136881933..136926615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518976.3XP_011517278.1  TNF receptor-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_011517278.1

    UniProtKB/Swiss-Prot
    Q12933
    UniProtKB/TrEMBL
    A0A024R8H5
    Conserved Domains (5) summary
    cd03778
    Location:334497
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178235
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:267329
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    cl28410
    Location:28157
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  2. XM_011518977.2XP_011517279.1  TNF receptor-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_011517279.1

    UniProtKB/Swiss-Prot
    Q12933
    UniProtKB/TrEMBL
    A0A024R8H5
    Conserved Domains (5) summary
    cd03778
    Location:334497
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178235
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:267329
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    cl28410
    Location:28157
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  3. XM_011518974.2XP_011517276.1  TNF receptor-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_011517276.1

    UniProtKB/Swiss-Prot
    Q12933
    UniProtKB/TrEMBL
    A0A024R8H5
    Conserved Domains (5) summary
    cd03778
    Location:334497
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178235
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:267329
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    cd16639
    Location:3273
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    cl28410
    Location:28157
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
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