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Wfdc3 WAP four-disulfide core domain 3 [ Mus musculus (house mouse) ]

Gene ID: 71856, updated on 5-Mar-2024

Summary

Official Symbol
Wfdc3provided by MGI
Official Full Name
WAP four-disulfide core domain 3provided by MGI
Primary source
MGI:MGI:1923897
See related
Ensembl:ENSMUSG00000076434 AllianceGenome:MGI:1923897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700015L13Rik; 1700127F16Rik
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; epididymis; and lung. Orthologous to human WFDC3 (WAP four-disulfide core domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 25.7) and genital fat pad adult (RPKM 2.2) See more
Orthologs
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Genomic context

See Wfdc3 in Genome Data Viewer
Location:
2 H3; 2 85.27 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164573222..164587914, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164731226..164745994, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serine protease inhibitor, Kunitz type 4 Neighboring gene serine protease inhibitor, Kunitz type 5 Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_06333 Neighboring gene STARR-positive B cell enhancer ABC_E417 Neighboring gene ubiquitin-conjugating enzyme E2C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
WAP four-disulfide core domain protein 3
Names
putative protease inhibitor WAP14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418734.1NP_001405663.1  WAP four-disulfide core domain protein 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL591127
    UniProtKB/Swiss-Prot
    Q14AE4
  2. NM_001418735.1NP_001405664.1  WAP four-disulfide core domain protein 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL591127
    UniProtKB/Swiss-Prot
    Q14AE4
  3. NM_027961.2NP_082237.1  WAP four-disulfide core domain protein 3 precursor

    See identical proteins and their annotated locations for NP_082237.1

    Status: VALIDATED

    Source sequence(s)
    AL591127
    Consensus CDS
    CCDS17053.1
    UniProtKB/Swiss-Prot
    Q14AE4
    Related
    ENSMUSP00000099385.4, ENSMUST00000103096.10
    Conserved Domains (1) summary
    pfam00095
    Location:2358
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RNA

  1. NR_184809.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591127
    Related
    ENSMUST00000109328.8
  2. NR_184810.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591127
    Related
    ENSMUST00000130227.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164573222..164587914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500193.3XP_006500256.1  WAP four-disulfide core domain protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006500256.1

    UniProtKB/Swiss-Prot
    Q14AE4
    Conserved Domains (1) summary
    pfam00095
    Location:2358
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
  2. XM_036162576.1XP_036018469.1  WAP four-disulfide core domain protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q14AE4
    Conserved Domains (1) summary
    pfam00095
    Location:2358
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
  3. XM_030252094.1XP_030107954.1  WAP four-disulfide core domain protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q14AE4
    Conserved Domains (1) summary
    pfam00095
    Location:2358
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'