Csl citrate synthase like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cslprovided by MGI
Official Full Name: citrate synthase likeprovided by MGI
Primary source: MGI:MGI:1919082
See related: Ensembl:ENSMUSG00000046934 AllianceGenome:MGI:1919082
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700007H16Rik
Summary: Predicted to enable citrate (Si)-synthase activity. Predicted to be involved in several processes, including acetyl-CoA metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Apr 2025]
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Genomic context

Location:: 10 D1; 10 51.2 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (99593567..99595346, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (99757705..99759658, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-12459 (e-PCR)
- UniSTS:28220

05.MMHAP6FRB8.seq (e-PCR)
- UniSTS:186290

General protein information

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Preferred Names: citrate synthase-like protein

NP_082221.2

EC 2.3.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027945.4 → NP_082221.2 citrate synthase-like protein

See identical proteins and their annotated locations for NP_082221.2

Status: VALIDATED

Source sequence(s)

AC158633

Consensus CDS

CCDS24149.1

UniProtKB/TrEMBL

F7D8H3, Q80X68, Q9DAM4

Related

ENSMUSP00000052373.5, ENSMUST00000056085.6

Conserved Domains (2) summary

cd06105
Location:33 → 459

ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...

PLN02456
Location:29 → 459

PLN02456; citrate synthase