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NR2C1 nuclear receptor subfamily 2 group C member 1 [ Homo sapiens (human) ]

Gene ID: 7181, updated on 11-Sep-2019

Summary

Official Symbol
NR2C1provided by HGNC
Official Full Name
nuclear receptor subfamily 2 group C member 1provided by HGNC
Primary source
HGNC:HGNC:7971
See related
Ensembl:ENSG00000120798 MIM:601529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR2
Summary
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 8.3), endometrium (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See NR2C1 in Genome Data Viewer
Location:
12q22
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (95020229..95073618, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (95414005..95467404, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369915 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene uncharacterized LOC112268099 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene ribosomal protein L14 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA upregulates NR2C1 gene expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear receptor subfamily 2 group C member 1
Names
TR2 nuclear hormone receptor
nuclear receptor subfamily 2, group C isoform
orphan nuclear receptor TR2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032287.3NP_001027458.1  nuclear receptor subfamily 2 group C member 1 isoform b

    See identical proteins and their annotated locations for NP_001027458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (b, also known as TR2-9) has a shorter C-terminus compared to isoform a.
    Source sequence(s)
    BC040141, DB266298
    Consensus CDS
    CCDS41821.1
    UniProtKB/Swiss-Prot
    P13056
    UniProtKB/TrEMBL
    H9NIM3
    Related
    ENSP00000376813.3, ENST00000393101.7
    Conserved Domains (2) summary
    cd06967
    Location:108194
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    cl11397
    Location:368464
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. NM_001127362.2NP_001120834.1  nuclear receptor subfamily 2 group C member 1 isoform c

    See identical proteins and their annotated locations for NP_001120834.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (c, also known as TR2-5) has a shorter C-terminus compared to isoform a.
    Source sequence(s)
    AK291319, BC040141, DB266298, M21985
    Consensus CDS
    CCDS44953.1
    UniProtKB/Swiss-Prot
    P13056
    Related
    ENSP00000328843.7, ENST00000330677.7
    Conserved Domains (2) summary
    cd06967
    Location:108194
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    cl11397
    Location:368465
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  3. NM_003297.4NP_003288.2  nuclear receptor subfamily 2 group C member 1 isoform a

    See identical proteins and their annotated locations for NP_003288.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as TR2-11).
    Source sequence(s)
    AC011598, AK291319, DB266298, JQ308177
    Consensus CDS
    CCDS9051.1
    UniProtKB/Swiss-Prot
    P13056
    UniProtKB/TrEMBL
    H9NIM2
    Related
    ENSP00000333275.4, ENST00000333003.10
    Conserved Domains (2) summary
    cd06952
    Location:368589
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:108194
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    95020229..95073618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538717.2XP_011537019.1  nuclear receptor subfamily 2 group C member 1 isoform X4

    Conserved Domains (2) summary
    cd06967
    Location:108194
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    cl11397
    Location:322493
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. XM_006719584.2XP_006719647.1  nuclear receptor subfamily 2 group C member 1 isoform X2

    Conserved Domains (2) summary
    cd06967
    Location:108194
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    cl11397
    Location:368543
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  3. XM_005269133.2XP_005269190.1  nuclear receptor subfamily 2 group C member 1 isoform X1

    Conserved Domains (2) summary
    cd06952
    Location:368584
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:108194
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  4. XM_011538716.2XP_011537018.1  nuclear receptor subfamily 2 group C member 1 isoform X3

    Conserved Domains (2) summary
    cd06967
    Location:108194
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    cl11397
    Location:368514
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  5. XM_006719585.2XP_006719648.1  nuclear receptor subfamily 2 group C member 1 isoform X5

    Conserved Domains (2) summary
    cd06952
    Location:191412
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cl02596
    Location:117
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

RNA

  1. XR_001748864.1 RNA Sequence

  2. XR_944699.2 RNA Sequence

  3. XR_429114.2 RNA Sequence

  4. XR_001748861.1 RNA Sequence

  5. XR_001748863.1 RNA Sequence

  6. XR_001748862.1 RNA Sequence

  7. XR_944700.1 RNA Sequence

  8. XR_245956.1 RNA Sequence

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