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Plekhf2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 [ Mus musculus (house mouse) ]

Gene ID: 71801, updated on 26-Sep-2022

Summary

Official Symbol
Plekhf2provided by MGI
Official Full Name
pleckstrin homology domain containing, family F (with FYVE domain) member 2provided by MGI
Primary source
MGI:MGI:1919051
See related
Ensembl:ENSMUSG00000049969 AllianceGenome:MGI:1919051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFYVE18; 1110070J07Rik
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in transport vesicle. Is expressed in bladder; male associated reproductive structure; testis; and urethra of male. Orthologous to human PLEKHF2 (pleckstrin homology and FYVE domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 15.0), liver E14 (RPKM 7.7) and 28 other tissues See more
Orthologs
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Genomic context

See Plekhf2 in Genome Data Viewer
Location:
4; 4 A1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (10988662..11007619, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (10988662..11007619, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S11, pseudogene 3 Neighboring gene 28S ribosomal protein S16, mitochondrial pseudogene Neighboring gene predicted gene, 46843 Neighboring gene predicted gene, 35429

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pleckstrin homology domain-containing family F member 2
Names
PH domain-containing family F member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175175.4NP_780384.1  pleckstrin homology domain-containing family F member 2

    See identical proteins and their annotated locations for NP_780384.1

    Status: VALIDATED

    Source sequence(s)
    AK033666, BC016134, BY167298
    Consensus CDS
    CCDS17962.1
    UniProtKB/Swiss-Prot
    Q91WB4
    Related
    ENSMUSP00000054745.4, ENSMUST00000054776.4
    Conserved Domains (3) summary
    cd01218
    Location:7129
    PH_Phafin2-like; Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) Pleckstrin Homology (PH) domain
    cd15755
    Location:148211
    FYVE_PKHF2; FYVE domain found in protein containing both PH and FYVE domains 2 (phafin-2) and similar proteins
    pfam00169
    Location:39130
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    10988662..11007619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)