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Ptcd1 pentatricopeptide repeat domain 1 [ Mus musculus (house mouse) ]

Gene ID: 71799, updated on 26-Sep-2022

Summary

Official Symbol
Ptcd1provided by MGI
Official Full Name
pentatricopeptide repeat domain 1provided by MGI
Primary source
MGI:MGI:1919049
See related
Ensembl:ENSMUSG00000029624 AllianceGenome:MGI:1919049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110069M14Rik
Summary
Predicted to enable tRNA binding activity. Involved in mitochondrial translation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in central nervous system and sensory organ. Orthologous to several human genes including PTCD1 (pentatricopeptide repeat domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 10.1), ovary adult (RPKM 8.7) and 28 other tissues See more
Orthologs
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Genomic context

See Ptcd1 in Genome Data Viewer
Location:
5; 5 G2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145084188..145103914, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145147378..145167104, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 1B Neighboring gene PDGFA associated protein 1 Neighboring gene BUD31 homolog Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102367

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pentatricopeptide repeat-containing protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133735.2NP_598496.3  pentatricopeptide repeat-containing protein 1, mitochondrial

    See identical proteins and their annotated locations for NP_598496.3

    Status: VALIDATED

    Source sequence(s)
    AC127411, BC083097
    Consensus CDS
    CCDS19858.1
    UniProtKB/Swiss-Prot
    Q8C2E4, Q99KB2
    Related
    ENSMUSP00000031628.10, ENSMUST00000031628.10
    Conserved Domains (3) summary
    TIGR00756
    Location:174206
    PPR; pentatricopeptide repeat domain (PPR motif)
    sd00004
    Location:174200
    PPR; PPR repeat [structural motif]
    pfam13041
    Location:551594
    PPR_2; PPR repeat family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    145084188..145103914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241013.4XP_011239315.1  pentatricopeptide repeat-containing protein 1, mitochondrial isoform X1

    Conserved Domains (3) summary
    PLN03218
    Location:125331
    PLN03218; maturation of RBCL 1; Provisional
    sd00004
    Location:174200
    PPR; PPR repeat [structural motif]
    pfam13041
    Location:174217
    PPR_2; PPR repeat family