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TPTE transmembrane phosphatase with tensin homology [ Homo sapiens (human) ]

Gene ID: 7179, updated on 7-Jun-2020

Summary

Official Symbol
TPTEprovided by HGNC
Official Full Name
transmembrane phosphatase with tensin homologyprovided by HGNC
Primary source
HGNC:HGNC:12023
See related
Ensembl:ENSG00000274391 MIM:604336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT44; PTEN2
Summary
This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Restricted expression toward testis (RPKM 57.8) See more
Orthologs

Genomic context

See TPTE in Genome Data Viewer
Location:
21p11.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (10521583..10605716)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (10906741..10990920, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 7 pseudogene Neighboring gene BAGE family member 2 Neighboring gene BAGE family member 2 Neighboring gene CYCS pseudogene 41 Neighboring gene solute carrier family 25 member 15 pseudogene 4 Neighboring gene immunoglobulin heavy variable 1/OR21-1 (non-functional)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane phosphatase with tensin homology (TPTE) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative tyrosine-protein phosphatase TPTE
Names
PTEN-related tyrosine phosphatase
cancer/testis antigen 44
tensin, putative protein-tyrosine phosphatase
tumor antigen BJ-HCC-5
NP_001277153.2
NP_954868.2
NP_954869.2
NP_954870.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034032.1 RefSeqGene

    Range
    5001..89757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290224.2NP_001277153.2  putative tyrosine-protein phosphatase TPTE isoform delta

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded protein (delta) has a shorter N-terminus, compared to isoform alpha.
    Source sequence(s)
    AF254983, AL078471
    Consensus CDS
    CCDS77617.1
    Related
    ENSP00000483087.1, ENST00000612746.1
  2. NM_199259.4NP_954868.2  putative tyrosine-protein phosphatase TPTE isoform beta

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame coding exon, compared to variant 1. The resulting protein (isoform beta) is missing an internal segment when compared to isoform alpha.
    Source sequence(s)
    AF254983, AL078471
    Consensus CDS
    CCDS74772.1
    Related
    ENSP00000482040.1, ENST00000622113.4
  3. NM_199260.4NP_954869.2  putative tyrosine-protein phosphatase TPTE isoform gamma

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame coding exons, compared to variant 1. The resulting protein (isoform gamma) is missing an internal segment when compared to isoform alpha.
    Source sequence(s)
    AF254983, AL078471
    Consensus CDS
    CCDS74773.1
    Related
    ENSP00000482488.1, ENST00000427445.6
  4. NM_199261.4NP_954870.3  putative tyrosine-protein phosphatase TPTE isoform alpha

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (alpha).
    Source sequence(s)
    AF254983, AL078471
    Consensus CDS
    CCDS74771.1
    Related
    ENSP00000484403.1, ENST00000618007.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    10521583..10605716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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