U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aox3 aldehyde oxidase 3 [ Mus musculus (house mouse) ]

Gene ID: 71724, updated on 18-Sep-2024

Summary

Official Symbol
Aox3provided by MGI
Official Full Name
aldehyde oxidase 3provided by MGI
Primary source
MGI:MGI:1918974
See related
Ensembl:ENSMUSG00000064294 AllianceGenome:MGI:1918974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aoh1; Aoh2; 1200011D03Rik
Summary
Enables aldehyde oxidase activity; electron transfer activity; and molybdenum ion binding activity. Predicted to be located in cytoplasm. Is expressed in nasal cavity. Orthologous to human AOX3P (aldehyde oxidase 3, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 21.0), liver E18 (RPKM 16.2) and 5 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Aox3 in Genome Data Viewer
Location:
1 C1.3; 1 28.96 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58152294..58241380)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58113135..58202221)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene shugoshin 2A Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene aldehyde oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_01004 Neighboring gene STARR-seq mESC enhancer starr_01005 Neighboring gene predicted gene, 39643 Neighboring gene predicted gene, 24548 Neighboring gene aldehyde oxidase 4 Neighboring gene predicted gene 15759 Neighboring gene aldehyde oxidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables aldehyde oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aldehyde oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aldehyde oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables electron transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin adenine dinucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables molybdenum ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molybdopterin cofactor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in xenobiotic metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
aldehyde oxidase 3
Names
aldehyde oxidase 1
aldehyde oxidase homolog 1
aldehyde oxidase structural homolog 2
azaheterocycle hydroxylase 3
NP_076106.2
XP_006496347.1
XP_006496348.1
XP_017167859.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023617.2NP_076106.2  aldehyde oxidase 3

    See identical proteins and their annotated locations for NP_076106.2

    Status: VALIDATED

    Source sequence(s)
    AC025116, AK004700, AK054065, AV275739, BB616838, BX633666
    Consensus CDS
    CCDS14969.1
    UniProtKB/Swiss-Prot
    B2RSI5, G3X982, Q8VI15
    UniProtKB/TrEMBL
    Q9ESH4
    Related
    ENSMUSP00000049391.8, ENSMUST00000040999.14
    Conserved Domains (6) summary
    TIGR02969
    Location:91334
    mam_aldehyde_ox; aldehyde oxidase
    smart01008
    Location:594697
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam00941
    Location:239419
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01799
    Location:91162
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:7091241
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:426530
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58152294..58241380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496285.4XP_006496348.1  aldehyde oxidase 3 isoform X2

    UniProtKB/TrEMBL
    Q9ESH4
    Conserved Domains (1) summary
    TIGR02969
    Location:11211
    mam_aldehyde_ox; aldehyde oxidase
  2. XM_006496284.5XP_006496347.1  aldehyde oxidase 3 isoform X1

    UniProtKB/TrEMBL
    Q9ESH4
    Conserved Domains (1) summary
    TIGR02969
    Location:11277
    mam_aldehyde_ox; aldehyde oxidase
  3. XM_017312370.3XP_017167859.1  aldehyde oxidase 3 isoform X3

    UniProtKB/TrEMBL
    Q9CW59
    Conserved Domains (1) summary
    TIGR02969
    Location:11110
    mam_aldehyde_ox; aldehyde oxidase