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Dhx35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 [ Mus musculus (house mouse) ]

Gene ID: 71715, updated on 9-Mar-2023

Summary

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Official Symbol
Dhx35provided by MGI
Official Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 35provided by MGI
Primary source
MGI:MGI:1918965
See related
Ensembl:ENSMUSG00000027655 AllianceGenome:MGI:1918965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddx35; 1200009D07Rik
Summary
Predicted to enable RNA binding activity. Acts upstream of or within in utero embryonic development. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human DHX35 (DEAH-box helicase 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 5.7), whole brain E14.5 (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dhx35 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158636674..158700141)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158794745..158858220)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene family with sequence similarity 83, member D Neighboring gene predicted gene, 38630 Neighboring gene predicted gene, 25090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
  2. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DHX35
NP_001278073.1
NP_001359442.1
NP_665685.1
XP_006500253.1
XP_030107952.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291144.2 → NP_001278073.1  probable ATP-dependent RNA helicase DHX35 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it also contains an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL669910
    Related
    ENSMUST00000145692.8
    Conserved Domains (5) summary
    smart00490
    Location:146 → 241
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:310 → 394
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:1 → 527
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:1 → 56
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:429 → 528
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. NM_001372513.2 → NP_001359442.1  probable ATP-dependent RNA helicase DHX35 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL669910
    Consensus CDS
    CCDS89575.1
    UniProtKB/TrEMBL
    A2ACQ1
    Related
    ENSMUSP00000105104.3, ENSMUST00000109478.9
    Conserved Domains (1) summary
    COG1643
    Location:21 → 682
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  3. NM_145742.3 → NP_665685.1  probable ATP-dependent RNA helicase DHX35 isoform a

    See identical proteins and their annotated locations for NP_665685.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AL669910
    Consensus CDS
    CCDS16993.1
    UniProtKB/TrEMBL
    Q8K1G9
    Related
    ENSMUSP00000029186.8, ENSMUST00000029186.14
    Conserved Domains (5) summary
    smart00490
    Location:301 → 396
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:53 → 224
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:465 → 549
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:73 → 211
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:584 → 659
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    158636674..158700141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500190.5 → XP_006500253.1  probable ATP-dependent RNA helicase DHX35 isoform X1

    Conserved Domains (1) summary
    COG1643
    Location:21 → 410
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  2. XM_030252092.2 → XP_030107952.1  probable ATP-dependent RNA helicase DHX35 isoform X2

    Conserved Domains (1) summary
    COG1643
    Location:2 → 390
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_003953722.2 RNA Sequence

  2. XR_004940734.1 RNA Sequence

  3. XR_004940735.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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