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Cdc5l cell division cycle 5-like [ Mus musculus (house mouse) ]

Gene ID: 71702, updated on 5-Mar-2024

Summary

Official Symbol
Cdc5lprovided by MGI
Official Full Name
cell division cycle 5-likeprovided by MGI
Primary source
MGI:MGI:1918952
See related
Ensembl:ENSMUSG00000023932 AllianceGenome:MGI:1918952
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PCDC5RP; 1200002I02Rik
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; enzyme binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including DNA damage checkpoint signaling; cellular response to nerve growth factor stimulus; and cellular response to wortmannin. Predicted to act upstream of or within DNA repair; RNA splicing; and mRNA processing. Predicted to be located in nuclear speck and perinuclear region of cytoplasm. Predicted to be part of DNA replication factor A complex; Prp19 complex; and U2-type catalytic step 2 spliceosome. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; limb; and maxillary process. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.3), CNS E14 (RPKM 10.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
17 B3; 17 22.36 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45702809..45744633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45391887..45433707, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41582 Neighboring gene predicted gene, 35204 Neighboring gene STARR-positive B cell enhancer ABC_E8677 Neighboring gene RIKEN cDNA B230354K17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5612 Neighboring gene STARR-seq mESC enhancer starr_42621 Neighboring gene spermatogenesis associated, serine-rich 1 Neighboring gene ribosomal protein L21 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables WD40-repeat domain binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to wortmannin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
 
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Prp19 complex ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cell division cycle 5-like protein
Names
cdc5-like protein
cell division cycle 5-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152810.2NP_690023.1  cell division cycle 5-like protein

    See identical proteins and their annotated locations for NP_690023.1

    Status: PROVISIONAL

    Source sequence(s)
    AC163677, AC169676
    Consensus CDS
    CCDS37627.1
    UniProtKB/Swiss-Prot
    Q6A068, Q8K1J9
    UniProtKB/TrEMBL
    Q3UCF2
    Related
    ENSMUSP00000024727.9, ENSMUST00000024727.10
    Conserved Domains (4) summary
    smart00717
    Location:856
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11659
    Location:56106
    SANT_CDC5_II; SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II
    pfam11831
    Location:404655
    Myb_Cef; pre-mRNA splicing factor component
    pfam13921
    Location:1171
    Myb_DNA-bind_6; Myb-like DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45702809..45744633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939578.1 RNA Sequence