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Pnpt1 polyribonucleotide nucleotidyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 71701, updated on 9-May-2024

Summary

Official Symbol
Pnpt1provided by MGI
Official Full Name
polyribonucleotide nucleotidyltransferase 1provided by MGI
Primary source
MGI:MGI:1918951
See related
Ensembl:ENSMUSG00000020464 AllianceGenome:MGI:1918951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Old35; PNPase; Pnptl1; 1200003F12Rik
Summary
Predicted to enable 3'-5'-exoribonuclease activity; RNA binding activity; and polyribonucleotide nucleotidyltransferase activity. Involved in mitochondrial mRNA catabolic process; mitochondrion morphogenesis; and regulation of cellular respiration. Located in mitochondrial intermembrane space. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 70 and combined oxidative phosphorylation deficiency 13. Orthologous to human PNPT1 (polyribonucleotide nucleotidyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 13.5), placenta adult (RPKM 11.3) and 26 other tissues See more
Orthologs
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Genomic context

See Pnpt1 in Genome Data Viewer
Location:
11 A3.3; 11 16.46 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29080236..29112010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29130129..29161827)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 1 Neighboring gene ribosomal protein SA, pseudogene 5 Neighboring gene STARR-seq mESC enhancer starr_29016 Neighboring gene STARR-seq mESC enhancer starr_29017 Neighboring gene STARR-seq mESC enhancer starr_29018 Neighboring gene STARR-seq mESC enhancer starr_29020 Neighboring gene RIKEN cDNA A630052C17 gene Neighboring gene STARR-positive B cell enhancer ABC_E1136 Neighboring gene protein phosphatase 4 regulatory subunit 3B Neighboring gene predicted gene, 51940

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables poly(G) binding ISO
Inferred from Sequence Orthology
more info
 
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables polyribonucleotide nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables polyribonucleotide nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA import into mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial RNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial RNA 5'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial RNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial mRNA polyadenylation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear polyadenylation-dependent mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial RNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA import into mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial degradosome ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
polyribonucleotide nucleotidyltransferase 1, mitochondrial
Names
3'-5' RNA exonuclease OLD35
PNPase 1
PNPase old-35
polynucleotide phosphorylase 1
polynucleotide phosphorylase-like protein
NP_082145.1
XP_006514876.1
XP_011242053.1
XP_030102190.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027869.2NP_082145.1  polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_082145.1

    Status: VALIDATED

    Source sequence(s)
    AK149419, BG092250, BX000351
    Consensus CDS
    CCDS24490.1
    UniProtKB/Swiss-Prot
    Q3UEP9, Q810U7, Q812B3, Q8K1R3, Q8R2U3, Q9DC52
    UniProtKB/TrEMBL
    Q3TST0, Q3UNL5
    Related
    ENSMUSP00000020756.9, ENSMUST00000020756.9
    Conserved Domains (1) summary
    PRK11824
    Location:47752
    PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional

RNA

  1. NR_157297.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK149419, AK152445, BX000351

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    29080236..29112010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243751.4XP_011242053.1  polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242053.1

    UniProtKB/Swiss-Prot
    Q3UEP9, Q810U7, Q812B3, Q8K1R3, Q8R2U3, Q9DC52
    UniProtKB/TrEMBL
    Q3TST0, Q3UNL5
    Conserved Domains (1) summary
    PRK11824
    Location:47752
    PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional
  2. XM_006514813.5XP_006514876.1  polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X3

    Conserved Domains (1) summary
    PRK11824
    Location:2461
    PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional
  3. XM_030246330.2XP_030102190.1  polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK11824
    Location:10472
    PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional