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Colec11 collectin sub-family member 11 [ Mus musculus (house mouse) ]

Gene ID: 71693, updated on 3-May-2022

Summary

Official Symbol
Colec11provided by MGI
Official Full Name
collectin sub-family member 11provided by MGI
Primary source
MGI:MGI:1918943
See related
Ensembl:ENSMUSG00000036655 AllianceGenome:MGI:1918943
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CL-K1
Summary
This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in the human gene are a cause of 3MC syndrome-2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Biased expression in liver adult (RPKM 12.7), liver E18 (RPKM 9.2) and 11 other tissues See more
Orthologs
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Genomic context

See Colec11 in Genome Data Viewer
Location:
12; 12 A2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (28644171..28673458, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (28594172..28623458, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (29279038..29308155, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene doublecortin domain containing 2C Neighboring gene allantoicase Neighboring gene predicted gene, 53713 Neighboring gene ribosomal protein S7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC129470, MGC129471, 1010001H16Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables fucose binding ISO
Inferred from Sequence Orthology
more info
 
enables mannose binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oligosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antimicrobial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in complement activation ISO
Inferred from Sequence Orthology
more info
 
involved_in complement activation, lectin pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of opsonization ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
collectin-11
Names
collectin kidney protein 1
collectin-L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313978.1NP_001300907.1  collectin-11 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC165283
    Consensus CDS
    CCDS88320.1
    UniProtKB/TrEMBL
    A0A1Y7VKG6
    Related
    ENSMUSP00000152876.2, ENSMUST00000220836.2
    Conserved Domains (2) summary
    cd03591
    Location:158273
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:4196
    Collagen; Collagen triple helix repeat (20 copies)
  2. NM_027866.2NP_082142.1  collectin-11 isoform 2 precursor

    See identical proteins and their annotated locations for NP_082142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC165283, AK003121, CF171867
    Consensus CDS
    CCDS36426.1
    UniProtKB/Swiss-Prot
    Q3SXB8
    UniProtKB/TrEMBL
    A0A0R4J0M6
    Related
    ENSMUSP00000049285.8, ENSMUST00000036136.9
    Conserved Domains (2) summary
    cd03591
    Location:152267
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:4899
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    28644171..28673458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515221.3XP_006515284.1  collectin-11 isoform X1

    See identical proteins and their annotated locations for XP_006515284.1

    Conserved Domains (1) summary
    cd03591
    Location:88203
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
  2. XM_030246930.2XP_030102790.1  collectin-11 isoform X1

    Conserved Domains (1) summary
    cd03591
    Location:88203
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
  3. XM_017315207.3XP_017170696.1  collectin-11 isoform X2

    Conserved Domains (1) summary
    pfam01391
    Location:4196
    Collagen; Collagen triple helix repeat (20 copies)